Pitfalls in the measurement of muscle mass: a need for a reference standard
Abstract Background All proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-04-01
|
| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.12268 |
| _version_ | 1827279476298350592 |
|---|---|
| author | Fanny Buckinx Francesco Landi Matteo Cesari Roger A. Fielding Marjolein Visser Klaus Engelke Stefania Maggi Elaine Dennison Nasser M. Al‐Daghri Sophie Allepaerts Jurgen Bauer Ivan Bautmans Maria Luisa Brandi Olivier Bruyère Tommy Cederholm Francesca Cerreta Antonio Cherubini Cyrus Cooper Alphonso Cruz‐Jentoft Eugene McCloskey Bess Dawson‐Hughes Jean‐Marc Kaufman Andrea Laslop Jean Petermans Jean‐Yves Reginster René Rizzoli Sian Robinson Yves Rolland Ricardo Rueda Bruno Vellas John A. Kanis |
| author_facet | Fanny Buckinx Francesco Landi Matteo Cesari Roger A. Fielding Marjolein Visser Klaus Engelke Stefania Maggi Elaine Dennison Nasser M. Al‐Daghri Sophie Allepaerts Jurgen Bauer Ivan Bautmans Maria Luisa Brandi Olivier Bruyère Tommy Cederholm Francesca Cerreta Antonio Cherubini Cyrus Cooper Alphonso Cruz‐Jentoft Eugene McCloskey Bess Dawson‐Hughes Jean‐Marc Kaufman Andrea Laslop Jean Petermans Jean‐Yves Reginster René Rizzoli Sian Robinson Yves Rolland Ricardo Rueda Bruno Vellas John A. Kanis |
| author_sort | Fanny Buckinx |
| collection | DOAJ |
| description | Abstract Background All proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia is hampered by limitations intrinsic to assessment tools. The aim of this study was to review the methods to assess muscle mass and to reach consensus on the development of a reference standard. Methods Literature reviews were performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis working group on frailty and sarcopenia. Face‐to‐face meetings were organized for the whole group to make amendments and discuss further recommendations. Results A wide range of techniques can be used to assess muscle mass. Cost, availability, and ease of use can determine whether the techniques are better suited to clinical practice or are more useful for research. No one technique subserves all requirements but dual energy X‐ray absorptiometry could be considered as a reference standard (but not a gold standard) for measuring muscle lean body mass. Conclusions Based on the feasibility, accuracy, safety, and low cost, dual energy X‐ray absorptiometry can be considered as the reference standard for measuring muscle mass. |
| first_indexed | 2024-04-24T08:19:35Z |
| format | Article |
| id | doaj.art-bdd42a45e3c74c59b6e973cbf5c8f10c |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-24T08:19:35Z |
| publishDate | 2018-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-bdd42a45e3c74c59b6e973cbf5c8f10c2024-04-17T01:51:12ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092018-04-019226927810.1002/jcsm.12268Pitfalls in the measurement of muscle mass: a need for a reference standardFanny Buckinx0Francesco Landi1Matteo Cesari2Roger A. Fielding3Marjolein Visser4Klaus Engelke5Stefania Maggi6Elaine Dennison7Nasser M. Al‐Daghri8Sophie Allepaerts9Jurgen Bauer10Ivan Bautmans11Maria Luisa Brandi12Olivier Bruyère13Tommy Cederholm14Francesca Cerreta15Antonio Cherubini16Cyrus Cooper17Alphonso Cruz‐Jentoft18Eugene McCloskey19Bess Dawson‐Hughes20Jean‐Marc Kaufman21Andrea Laslop22Jean Petermans23Jean‐Yves Reginster24René Rizzoli25Sian Robinson26Yves Rolland27Ricardo Rueda28Bruno Vellas29John A. Kanis30Department of Public Health, Epidemiology and Health Economics University of Liège Liège BelgiumDepartment of Geriatrics, Neurosciences and Orthopedics Catholic University of the Sacred Heart Rome Milan ItalyGérontopôle University Hospital of Toulouse Toulouse FranceNutrition, Exercise Physiology and Sarcopenia Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Boston MA 02111 USADepartment of Health Sciences VU University Amsterdam Amsterdam NetherlandsInstitute of Medical Physics, University of Erlangen Erlangen GermanyNational Research Council Neuroscience Institute, Aging Branch Padova ItalyMRC Lifecourse Epidemiology Unit University of Southampton Southampton England UKPrince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science King Saud University Riyadh 11451 Saudi ArabiaDepartment of Geriatrics CHU‐Liège Liège BelgiumDepartment of Geriatric Medicine, Klinikum Carl von Ossietzky University Oldenburg GermanyGerontology and Frailty in Ageing Research Department Vrije Universiteit Brussel (VUB) Brussels BelgiumDepartment of Surgery and Translational Medicine University of Florence viale Pieraccini 6 59139 Florence ItalyDepartment of Public Health, Epidemiology and Health Economics University of Liège Liège BelgiumHuman Medicines Research and Development Support Division, Scientific Advice London UKHuman Medicines Research and Development Support Division, Scientific Advice London UKGeriatrics and Geriatric Emergency Care, IRCCS‐INRCA Ancona ItalyMRC Lifecourse Epidemiology Unit University of Southampton Southampton England UKHospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis) Madrid SpainCentre for Metabolic Bone Diseases University of Sheffield Sheffield UKJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University Boston MA USADepartment of Endocrinology and Unit for Osteoporosis and Metabolic Bone Diseases Ghent University Hospital Ghent BelgiumScientific Office, Austrian Agency for Health and Food Safety Vienna AustriaDepartment of Geriatrics CHU‐Liège Liège BelgiumDepartment of Public Health, Epidemiology and Health Economics University of Liège Liège BelgiumService of Bone Diseases, Department of Internal Medicine Specialties Geneva University Hospitals and Faculty of Medicine Geneva SwitzerlandMRC Lifecourse Epidemiology Unit University of Southampton Southampton England UKGérontopôle de Toulouse Institut du Vieillissement, Centre Hospitalo‐Universitaire de Toulouse (CHU Toulouse); UMR INSERM 1027, University of Toulouse III Toulouse FranceAbbott Nutrition R&D Granada SpainGérontopôle de Toulouse Institut du Vieillissement, Centre Hospitalo‐Universitaire de Toulouse (CHU Toulouse); UMR INSERM 1027, University of Toulouse III Toulouse FranceCentre for Metabolic Bone Diseases University of Sheffield, UK and Institute of Health and Ageing, Australian Catholic University Melbourne AustraliaAbstract Background All proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia is hampered by limitations intrinsic to assessment tools. The aim of this study was to review the methods to assess muscle mass and to reach consensus on the development of a reference standard. Methods Literature reviews were performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis working group on frailty and sarcopenia. Face‐to‐face meetings were organized for the whole group to make amendments and discuss further recommendations. Results A wide range of techniques can be used to assess muscle mass. Cost, availability, and ease of use can determine whether the techniques are better suited to clinical practice or are more useful for research. No one technique subserves all requirements but dual energy X‐ray absorptiometry could be considered as a reference standard (but not a gold standard) for measuring muscle lean body mass. Conclusions Based on the feasibility, accuracy, safety, and low cost, dual energy X‐ray absorptiometry can be considered as the reference standard for measuring muscle mass.https://doi.org/10.1002/jcsm.12268Lean massMuscle massLean body massReference standard |
| spellingShingle | Fanny Buckinx Francesco Landi Matteo Cesari Roger A. Fielding Marjolein Visser Klaus Engelke Stefania Maggi Elaine Dennison Nasser M. Al‐Daghri Sophie Allepaerts Jurgen Bauer Ivan Bautmans Maria Luisa Brandi Olivier Bruyère Tommy Cederholm Francesca Cerreta Antonio Cherubini Cyrus Cooper Alphonso Cruz‐Jentoft Eugene McCloskey Bess Dawson‐Hughes Jean‐Marc Kaufman Andrea Laslop Jean Petermans Jean‐Yves Reginster René Rizzoli Sian Robinson Yves Rolland Ricardo Rueda Bruno Vellas John A. Kanis Pitfalls in the measurement of muscle mass: a need for a reference standard Journal of Cachexia, Sarcopenia and Muscle Lean mass Muscle mass Lean body mass Reference standard |
| title | Pitfalls in the measurement of muscle mass: a need for a reference standard |
| title_full | Pitfalls in the measurement of muscle mass: a need for a reference standard |
| title_fullStr | Pitfalls in the measurement of muscle mass: a need for a reference standard |
| title_full_unstemmed | Pitfalls in the measurement of muscle mass: a need for a reference standard |
| title_short | Pitfalls in the measurement of muscle mass: a need for a reference standard |
| title_sort | pitfalls in the measurement of muscle mass a need for a reference standard |
| topic | Lean mass Muscle mass Lean body mass Reference standard |
| url | https://doi.org/10.1002/jcsm.12268 |
| work_keys_str_mv | AT fannybuckinx pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT francescolandi pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT matteocesari pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT rogerafielding pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT marjoleinvisser pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT klausengelke pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT stefaniamaggi pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT elainedennison pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT nassermaldaghri pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT sophieallepaerts pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT jurgenbauer pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT ivanbautmans pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT marialuisabrandi pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT olivierbruyere pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT tommycederholm pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT francescacerreta pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT antoniocherubini pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT cyruscooper pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT alphonsocruzjentoft pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT eugenemccloskey pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT bessdawsonhughes pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT jeanmarckaufman pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT andrealaslop pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT jeanpetermans pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT jeanyvesreginster pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT renerizzoli pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT sianrobinson pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT yvesrolland pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT ricardorueda pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT brunovellas pitfallsinthemeasurementofmusclemassaneedforareferencestandard AT johnakanis pitfallsinthemeasurementofmusclemassaneedforareferencestandard |