Progress, prospects, and limitations of organoid technology
Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs. In recent research, various organoids have been derived from pluripotent stem cells or multipotent organ-specific adult stem cells in vitro and hav...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Organoid Society
2022-04-01
|
| Series: | Organoid |
| Subjects: | |
| Online Access: | http://j-organoid.org/upload/pdf/organoid-2022-2-e9.pdf |
| _version_ | 1797768364644368384 |
|---|---|
| author | Jin Hee Park Do Gyeung Byeun Jung Kyu Choi |
| author_facet | Jin Hee Park Do Gyeung Byeun Jung Kyu Choi |
| author_sort | Jin Hee Park |
| collection | DOAJ |
| description | Organoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs. In recent research, various organoids have been derived from pluripotent stem cells or multipotent organ-specific adult stem cells in vitro and have been used in regenerative medicine, disease modeling, precision medicine, toxicology studies, and drug discovery. However, research on reproduction-related organoids has not been comprehensive, and some limitations need to be addressed for culturing these organoids. In this review, we discuss the historical advances, major recent developments, limitations, and potential of organoid culture, including human reproductive organoids. |
| first_indexed | 2024-03-12T20:53:25Z |
| format | Article |
| id | doaj.art-bdd8229dbe5241df9a9fda87fe60a03c |
| institution | Directory Open Access Journal |
| issn | 2765-205X |
| language | English |
| last_indexed | 2024-03-12T20:53:25Z |
| publishDate | 2022-04-01 |
| publisher | The Organoid Society |
| record_format | Article |
| series | Organoid |
| spelling | doaj.art-bdd8229dbe5241df9a9fda87fe60a03c2023-08-01T00:42:00ZengThe Organoid SocietyOrganoid2765-205X2022-04-01210.51335/organoid.2022.2.e922Progress, prospects, and limitations of organoid technologyJin Hee Park0Do Gyeung Byeun1Jung Kyu Choi Department of Biotechnology, College of Life and Applied Sciences, Yeungnam University, Gyeongsan 38541, Korea Department of Biotechnology, College of Life and Applied Sciences, Yeungnam University, Gyeongsan 38541, KoreaOrganoids are mini-organs generated through in vitro 3-dimensional culture that mimic some of the structural and physiological functions of real organs. In recent research, various organoids have been derived from pluripotent stem cells or multipotent organ-specific adult stem cells in vitro and have been used in regenerative medicine, disease modeling, precision medicine, toxicology studies, and drug discovery. However, research on reproduction-related organoids has not been comprehensive, and some limitations need to be addressed for culturing these organoids. In this review, we discuss the historical advances, major recent developments, limitations, and potential of organoid culture, including human reproductive organoids.http://j-organoid.org/upload/pdf/organoid-2022-2-e9.pdforganoidsstem cellsregenerative medicinereproductionmicrofluidics |
| spellingShingle | Jin Hee Park Do Gyeung Byeun Jung Kyu Choi Progress, prospects, and limitations of organoid technology Organoid organoids stem cells regenerative medicine reproduction microfluidics |
| title | Progress, prospects, and limitations of organoid technology |
| title_full | Progress, prospects, and limitations of organoid technology |
| title_fullStr | Progress, prospects, and limitations of organoid technology |
| title_full_unstemmed | Progress, prospects, and limitations of organoid technology |
| title_short | Progress, prospects, and limitations of organoid technology |
| title_sort | progress prospects and limitations of organoid technology |
| topic | organoids stem cells regenerative medicine reproduction microfluidics |
| url | http://j-organoid.org/upload/pdf/organoid-2022-2-e9.pdf |
| work_keys_str_mv | AT jinheepark progressprospectsandlimitationsoforganoidtechnology AT dogyeungbyeun progressprospectsandlimitationsoforganoidtechnology AT jungkyuchoi progressprospectsandlimitationsoforganoidtechnology |