Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report
<i>Background and objective:</i> Coronary artery disease is one of the leading causes of deaths nowadays and the trends in diagnosis and revascularization are still in plateau despite well-known factors. Simple whole blood count parameters may be used to measure inflammatory reactions th...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/12/1324 |
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| author | Tomasz Urbanowicz Michał Michalak Anna Olasińska-Wiśniewska Anna Witkowska Michał Rodzki Ewelina Błażejowska Aleksandra Gąsecka Bartłomiej Perek Marek Jemielity |
| author_facet | Tomasz Urbanowicz Michał Michalak Anna Olasińska-Wiśniewska Anna Witkowska Michał Rodzki Ewelina Błażejowska Aleksandra Gąsecka Bartłomiej Perek Marek Jemielity |
| author_sort | Tomasz Urbanowicz |
| collection | DOAJ |
| description | <i>Background and objective:</i> Coronary artery disease is one of the leading causes of deaths nowadays and the trends in diagnosis and revascularization are still in plateau despite well-known factors. Simple whole blood count parameters may be used to measure inflammatory reactions that are involved in processes of atherosclerosis progression. The aim of our study was to analyse the association between simply available hematologic indices and long-term mortality following off-pump coronary artery bypass grafting (OPCAB). <i>Material and Methods:</i> The study group comprised 129 consecutive patients (16 females and 113 males, mean age 66 ± 6 years) who underwent surgical revascularization with off-pump technique between January 2014 and September 2019. The mean follow-up was 4.7 +/−1.9 years. A receiver operating characteristics curve was applied to estimate demographical and perioperative parameters including MLR for mortality. <i>Results:</i> Cox regression analysis revealed chronic pulmonary obstructive disease (HR = 2.86, 95%CI 1.05–7.78), MLR (HR = 3.81, 95%CI 1.45–10.06) and right coronary artery blood flow (HR = 1.06, 95%CI 1.00–1.10) as significant factors predicting increased mortality risk. In the presented model, the MLR > 1.44 on 1st postoperative day was a significant predictor of late mortality after the OPCAB procedure (HR = 3.82, 95%CI 1.45–10.06). <i>Conclusions:</i> Pronounced inflammatory reaction after off-pump surgery measured by MLR > 1.44 can be regarded as a worse long-term prognostic factor. |
| first_indexed | 2024-03-10T03:37:31Z |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T03:37:31Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-bddb2345f64f4b7da3fd6a21801953ab2023-11-23T09:28:23ZengMDPI AGMedicina1010-660X1648-91442021-12-015712132410.3390/medicina57121324Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial ReportTomasz Urbanowicz0Michał Michalak1Anna Olasińska-Wiśniewska2Anna Witkowska3Michał Rodzki4Ewelina Błażejowska5Aleksandra Gąsecka6Bartłomiej Perek7Marek Jemielity8Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, 61-701 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland1st Chair and Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, PolandCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-701 Poznan, Poland<i>Background and objective:</i> Coronary artery disease is one of the leading causes of deaths nowadays and the trends in diagnosis and revascularization are still in plateau despite well-known factors. Simple whole blood count parameters may be used to measure inflammatory reactions that are involved in processes of atherosclerosis progression. The aim of our study was to analyse the association between simply available hematologic indices and long-term mortality following off-pump coronary artery bypass grafting (OPCAB). <i>Material and Methods:</i> The study group comprised 129 consecutive patients (16 females and 113 males, mean age 66 ± 6 years) who underwent surgical revascularization with off-pump technique between January 2014 and September 2019. The mean follow-up was 4.7 +/−1.9 years. A receiver operating characteristics curve was applied to estimate demographical and perioperative parameters including MLR for mortality. <i>Results:</i> Cox regression analysis revealed chronic pulmonary obstructive disease (HR = 2.86, 95%CI 1.05–7.78), MLR (HR = 3.81, 95%CI 1.45–10.06) and right coronary artery blood flow (HR = 1.06, 95%CI 1.00–1.10) as significant factors predicting increased mortality risk. In the presented model, the MLR > 1.44 on 1st postoperative day was a significant predictor of late mortality after the OPCAB procedure (HR = 3.82, 95%CI 1.45–10.06). <i>Conclusions:</i> Pronounced inflammatory reaction after off-pump surgery measured by MLR > 1.44 can be regarded as a worse long-term prognostic factor.https://www.mdpi.com/1648-9144/57/12/1324OPCABMLRinflammatory responsesurvival |
| spellingShingle | Tomasz Urbanowicz Michał Michalak Anna Olasińska-Wiśniewska Anna Witkowska Michał Rodzki Ewelina Błażejowska Aleksandra Gąsecka Bartłomiej Perek Marek Jemielity Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report Medicina OPCAB MLR inflammatory response survival |
| title | Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report |
| title_full | Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report |
| title_fullStr | Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report |
| title_full_unstemmed | Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report |
| title_short | Monocyte-to-Lymphocyte Ratio as a Predictor of Worse Long-Term Survival after Off-Pump Surgical Revascularization-Initial Report |
| title_sort | monocyte to lymphocyte ratio as a predictor of worse long term survival after off pump surgical revascularization initial report |
| topic | OPCAB MLR inflammatory response survival |
| url | https://www.mdpi.com/1648-9144/57/12/1324 |
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