Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions
Oral premalignant lesions (OPLs) and numerous alterations of oral mucosa remain unsolved due to their complex etiopathogenesis. Human papillomaviruses (HPVs), in particular, have been reported as the possible risk factors or cofactors. The aim of the study was to determine the association of differe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2017-01-01
|
| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/281917 |
| _version_ | 1797207769571393536 |
|---|---|
| author | Lindita Zendeli-Bedjeti Mirjana Popovska Aneta Atanasovska-Stojanovska Sotirija Duvlis |
| author_facet | Lindita Zendeli-Bedjeti Mirjana Popovska Aneta Atanasovska-Stojanovska Sotirija Duvlis |
| author_sort | Lindita Zendeli-Bedjeti |
| collection | DOAJ |
| description | Oral premalignant lesions (OPLs) and numerous alterations of oral mucosa remain unsolved due to their complex etiopathogenesis. Human papillomaviruses (HPVs), in particular, have been reported as the possible risk factors or cofactors. The aim of the study was to determine the association of different HPV types with oral premalignant lesions, and the potential role of smoking and alcohol use. Eighty patients (mean age ± SD, 52.45±5.56) of both genders, 19 (23.75%) male and 61 (76.25%) female, were enrolled in the study. Study group included 40 patients diagnosed with OPLs (leukoplakia, erythroplakia, actinic keratosis and lichen planus), while control group included another 40 patients with healthy oral mucosa. Genotyping of the HPV types was performed by qualitative real-time HPV typing polymerase chain reaction test. HPV DNA was detected in 30% (12/40) of study group patients and 2.5% (1/40) of control group patients. The results revealed the presence of HPV16 in 15% (6/40), HPV56 in 10% (4/40), and HPV18 in 5% (2/40) of study group cases, and HPV31 in 1 (2.5%) control group patient. Th e association of oral HPV positivity and smoking/alcohol use in the study group was not statistically signifi cant (p>0.05). In conclusion, high-risk HPV types are associated with oral premalignant disorders. However, it remains unknown whether HPV acts as an innocent bystander or it has a role in initiating development of premalignant lesions. Smoking and alcohol use were not associated with the existing oral HPV infection. |
| first_indexed | 2024-04-24T09:28:11Z |
| format | Article |
| id | doaj.art-bddc760655c54973ab7ae1aab7ef3023 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:28:11Z |
| publishDate | 2017-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-bddc760655c54973ab7ae1aab7ef30232024-04-15T14:30:26ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512017-01-0156.3.36937410.20471/acc.2017.56.03.02Human Papillomavirus as a Potential Risk Factor for Oral Premalignant LesionsLindita Zendeli-Bedjeti0Mirjana Popovska1Aneta Atanasovska-Stojanovska2Sotirija Duvlis3Department of Oral Pathology and Periodontology, St. Panteleimon University Dental Clinical Center, Skopje, Republic of MacedoniaDepartment of Oral Pathology and Periodontology, St. Panteleimon University Dental Clinical Center, Skopje, Republic of Macedonia ;School of Dental Medicine, Skopje, Republic of MacedoniaDepartment of Oral Pathology and Periodontology, St. Panteleimon University Dental Clinical Center, Skopje, Republic of Macedonia ;School of Dental Medicine, Skopje, Republic of MacedoniaInstitute of Public Health, Skopje, Republic of MacedoniaOral premalignant lesions (OPLs) and numerous alterations of oral mucosa remain unsolved due to their complex etiopathogenesis. Human papillomaviruses (HPVs), in particular, have been reported as the possible risk factors or cofactors. The aim of the study was to determine the association of different HPV types with oral premalignant lesions, and the potential role of smoking and alcohol use. Eighty patients (mean age ± SD, 52.45±5.56) of both genders, 19 (23.75%) male and 61 (76.25%) female, were enrolled in the study. Study group included 40 patients diagnosed with OPLs (leukoplakia, erythroplakia, actinic keratosis and lichen planus), while control group included another 40 patients with healthy oral mucosa. Genotyping of the HPV types was performed by qualitative real-time HPV typing polymerase chain reaction test. HPV DNA was detected in 30% (12/40) of study group patients and 2.5% (1/40) of control group patients. The results revealed the presence of HPV16 in 15% (6/40), HPV56 in 10% (4/40), and HPV18 in 5% (2/40) of study group cases, and HPV31 in 1 (2.5%) control group patient. Th e association of oral HPV positivity and smoking/alcohol use in the study group was not statistically signifi cant (p>0.05). In conclusion, high-risk HPV types are associated with oral premalignant disorders. However, it remains unknown whether HPV acts as an innocent bystander or it has a role in initiating development of premalignant lesions. Smoking and alcohol use were not associated with the existing oral HPV infection.https://hrcak.srce.hr/file/281917Mouth diseasesPapillomaviridaeHuman papillomavirus 16Polymerase chain reactionMacedonia |
| spellingShingle | Lindita Zendeli-Bedjeti Mirjana Popovska Aneta Atanasovska-Stojanovska Sotirija Duvlis Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions Acta Clinica Croatica Mouth diseases Papillomaviridae Human papillomavirus 16 Polymerase chain reaction Macedonia |
| title | Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions |
| title_full | Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions |
| title_fullStr | Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions |
| title_full_unstemmed | Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions |
| title_short | Human Papillomavirus as a Potential Risk Factor for Oral Premalignant Lesions |
| title_sort | human papillomavirus as a potential risk factor for oral premalignant lesions |
| topic | Mouth diseases Papillomaviridae Human papillomavirus 16 Polymerase chain reaction Macedonia |
| url | https://hrcak.srce.hr/file/281917 |
| work_keys_str_mv | AT linditazendelibedjeti humanpapillomavirusasapotentialriskfactorfororalpremalignantlesions AT mirjanapopovska humanpapillomavirusasapotentialriskfactorfororalpremalignantlesions AT anetaatanasovskastojanovska humanpapillomavirusasapotentialriskfactorfororalpremalignantlesions AT sotirijaduvlis humanpapillomavirusasapotentialriskfactorfororalpremalignantlesions |