Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with Knee Osteoarthritis and Sarcopenia
Knee osteoarthritis (KOA) is closely associated with sarcopenia, sharing the common characteristics of muscle weakness and low physical performance. Resistance exercise training (RET), protein supplementation (PS), and PS+RET have promise as treatments for both sarcopenia and KOA. However, whether P...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/7/1552 |
| _version_ | 1797607288674975744 |
|---|---|
| author | Chun-De Liao Shih-Wei Huang Hung-Chou Chen Yu-Yun Huang Tsan-Hon Liou Che-Li Lin |
| author_facet | Chun-De Liao Shih-Wei Huang Hung-Chou Chen Yu-Yun Huang Tsan-Hon Liou Che-Li Lin |
| author_sort | Chun-De Liao |
| collection | DOAJ |
| description | Knee osteoarthritis (KOA) is closely associated with sarcopenia, sharing the common characteristics of muscle weakness and low physical performance. Resistance exercise training (RET), protein supplementation (PS), and PS+RET have promise as treatments for both sarcopenia and KOA. However, whether PS+RET exerts any effect on time to recovery to normal walking speed (WS) in older adults with sarcopenia and KOA remains unclear. This study investigated the treatment efficiency of PS+RET on WS recovery among individuals with KOA and sarcopenia. A total of 108 older adults aged ≥ 60 years who had a diagnosis of radiographic KOA and sarcopenia were enrolled in this prospective cohort study. Sarcopenia was defined on the basis of the cutoff values of the appendicular skeletal muscle mass index for Asian people and a slow WS less than 1.0 m/s. The patients were equally distributed to three groups: PS+RET, RET alone, and usual care. The weekly assessment was performed during a 12-week intervention and a subsequent 36-week follow-up period. A cutoff of 1.0 m/s was used to identify successful recovery to normal WS. Kaplan–Meier analysis was performed to measure the survival time to normal WS among the study groups. Multivariate Cox proportional-hazards regression (CPHR) models were established to calculate the hazard ratios (HRs) of successful WS recovery and determine its potential moderators. After the 3-month intervention, PS+RET as well as RET obtained greater changes in WS by an adjusted mean difference of 0.18 m/s (<i>p</i> < 0.0001) and 0.08 (<i>p</i> < 0.05) m/s, respectively, compared to usual care. Kaplan–Meier analysis results showed both RET and PS+RET interventions yielded high probabilities of achieving normal WS over the 12-month follow-up period. Multivariate CPHR results revealed that PS+RET (adjusted HR = 5.48; <i>p</i> < 0.001), as well as RET (adjusted HR = 2.21; <i>p</i> < 0.05), independently exerted significant effects on WS recovery. PS+RET may accelerate normal WS recovery by approximately 3 months compared with RET. Sex and initial WS may influence the treatment efficiency. For patients with KOA who suffer sarcopenia, 12-week RET alone exerts significant effects on WS recovery, whereas additional PS further augments the treatment effects of RET by speeding up the recovery time of WS toward a level ≥ 1.0 m/s, which facilitates the patients to diminish the disease severity or even free from sarcopenia. |
| first_indexed | 2024-03-11T05:29:05Z |
| format | Article |
| id | doaj.art-bddcbf4b48364cce85ee54e0ccdd6a33 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T05:29:05Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-bddcbf4b48364cce85ee54e0ccdd6a332023-11-17T17:18:34ZengMDPI AGNutrients2072-66432023-03-01157155210.3390/nu15071552Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with Knee Osteoarthritis and SarcopeniaChun-De Liao0Shih-Wei Huang1Hung-Chou Chen2Yu-Yun Huang3Tsan-Hon Liou4Che-Li Lin5International Ph.D. Program in Gerontology and Long-Term Care, College of Nursing, Taipei Medical University, Taipei 110301, TaiwanDepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, TaiwanDepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, TaiwanDepartment of Pediatrics, New York University Langone Medical Center, New York City, NY 10016, USADepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, New Taipei City 235041, TaiwanDepartment of Orthopedic Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, TaiwanKnee osteoarthritis (KOA) is closely associated with sarcopenia, sharing the common characteristics of muscle weakness and low physical performance. Resistance exercise training (RET), protein supplementation (PS), and PS+RET have promise as treatments for both sarcopenia and KOA. However, whether PS+RET exerts any effect on time to recovery to normal walking speed (WS) in older adults with sarcopenia and KOA remains unclear. This study investigated the treatment efficiency of PS+RET on WS recovery among individuals with KOA and sarcopenia. A total of 108 older adults aged ≥ 60 years who had a diagnosis of radiographic KOA and sarcopenia were enrolled in this prospective cohort study. Sarcopenia was defined on the basis of the cutoff values of the appendicular skeletal muscle mass index for Asian people and a slow WS less than 1.0 m/s. The patients were equally distributed to three groups: PS+RET, RET alone, and usual care. The weekly assessment was performed during a 12-week intervention and a subsequent 36-week follow-up period. A cutoff of 1.0 m/s was used to identify successful recovery to normal WS. Kaplan–Meier analysis was performed to measure the survival time to normal WS among the study groups. Multivariate Cox proportional-hazards regression (CPHR) models were established to calculate the hazard ratios (HRs) of successful WS recovery and determine its potential moderators. After the 3-month intervention, PS+RET as well as RET obtained greater changes in WS by an adjusted mean difference of 0.18 m/s (<i>p</i> < 0.0001) and 0.08 (<i>p</i> < 0.05) m/s, respectively, compared to usual care. Kaplan–Meier analysis results showed both RET and PS+RET interventions yielded high probabilities of achieving normal WS over the 12-month follow-up period. Multivariate CPHR results revealed that PS+RET (adjusted HR = 5.48; <i>p</i> < 0.001), as well as RET (adjusted HR = 2.21; <i>p</i> < 0.05), independently exerted significant effects on WS recovery. PS+RET may accelerate normal WS recovery by approximately 3 months compared with RET. Sex and initial WS may influence the treatment efficiency. For patients with KOA who suffer sarcopenia, 12-week RET alone exerts significant effects on WS recovery, whereas additional PS further augments the treatment effects of RET by speeding up the recovery time of WS toward a level ≥ 1.0 m/s, which facilitates the patients to diminish the disease severity or even free from sarcopenia.https://www.mdpi.com/2072-6643/15/7/1552sarcopeniaosteoarthritisprotein supplementexercisemobility |
| spellingShingle | Chun-De Liao Shih-Wei Huang Hung-Chou Chen Yu-Yun Huang Tsan-Hon Liou Che-Li Lin Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with Knee Osteoarthritis and Sarcopenia Nutrients sarcopenia osteoarthritis protein supplement exercise mobility |
| title | Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with Knee Osteoarthritis and Sarcopenia |
| title_full | Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with Knee Osteoarthritis and Sarcopenia |
| title_fullStr | Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with Knee Osteoarthritis and Sarcopenia |
| title_full_unstemmed | Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with Knee Osteoarthritis and Sarcopenia |
| title_short | Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with Knee Osteoarthritis and Sarcopenia |
| title_sort | effects of protein supplementation combined with resistance exercise training on walking speed recovery in older adults with knee osteoarthritis and sarcopenia |
| topic | sarcopenia osteoarthritis protein supplement exercise mobility |
| url | https://www.mdpi.com/2072-6643/15/7/1552 |
| work_keys_str_mv | AT chundeliao effectsofproteinsupplementationcombinedwithresistanceexercisetrainingonwalkingspeedrecoveryinolderadultswithkneeosteoarthritisandsarcopenia AT shihweihuang effectsofproteinsupplementationcombinedwithresistanceexercisetrainingonwalkingspeedrecoveryinolderadultswithkneeosteoarthritisandsarcopenia AT hungchouchen effectsofproteinsupplementationcombinedwithresistanceexercisetrainingonwalkingspeedrecoveryinolderadultswithkneeosteoarthritisandsarcopenia AT yuyunhuang effectsofproteinsupplementationcombinedwithresistanceexercisetrainingonwalkingspeedrecoveryinolderadultswithkneeosteoarthritisandsarcopenia AT tsanhonliou effectsofproteinsupplementationcombinedwithresistanceexercisetrainingonwalkingspeedrecoveryinolderadultswithkneeosteoarthritisandsarcopenia AT chelilin effectsofproteinsupplementationcombinedwithresistanceexercisetrainingonwalkingspeedrecoveryinolderadultswithkneeosteoarthritisandsarcopenia |