Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal study
Abstract Background Studies on higher doses of sugammadex effect on QT interval and leading arrhythmia have been limited. In this study, we aimed to investigate possible proarrhythmic effect of higher doses of sugammadex in conditions that required urgent reversal of neuromuscular blockade during ge...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Journal of Anesthesia, Analgesia and Critical Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s44158-022-00077-0 |
| _version_ | 1828086840713805824 |
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| author | Emin Tunç Demir Mesut Erbaş |
| author_facet | Emin Tunç Demir Mesut Erbaş |
| author_sort | Emin Tunç Demir |
| collection | DOAJ |
| description | Abstract Background Studies on higher doses of sugammadex effect on QT interval and leading arrhythmia have been limited. In this study, we aimed to investigate possible proarrhythmic effect of higher doses of sugammadex in conditions that required urgent reversal of neuromuscular blockade during general anesthesia in an experimental animal model. Methods It was experimental animal study. Total of 15 male New Zealand rabbits were randomly divided into three groups for low (4 mg/kg, n = 5), moderate (16 mg/kg, n = 5), and high dose of sugammadex (32 mg/kg, n = 5). All rabbits were premedicated by intramuscular ketamine 10 mg/kg, and general anesthesia was inducted by intravenous injection of 2 mg/kg of a propofol, 1 mcg/kg fentanyl, and 0.6 mg/kg rocuronium injection. Airway was provided by V-gel rabbit and connected to anesthetic device and ventilated at about 40 cycle/min and 10 ml/kg; oxygen 50% plus air 50% mixture was used with 1 MAC isoflurane to maintain anesthesia. Electrocardiographic monitorization and arterial cannulation were provided to follow-up mean arterial pressure and for arterial blood gas analyses. Intravenous sugammadex in three different doses were injected at 25th min of induction. After observing adequate respiration of all rabbits, V-gel rabbit was removed. Parameters and ECG recordings were taken basal value before induction and at the 5th, 10th, 20th, 25th, 30th, and 40th min to measure corrected QT intervals and were stored on digital media. QT interval was calculated as the time from the beginning of the Q wave to the end of the T wave. Corrected QT interval was calculated according to the Bazett’s formula. Possible adverse effects were observed and recorded. Results In all three groups, there was no significant statistical difference in mean arterial blood gases parameters, arterial pressures, heart rates, and Bazett QTc values, and no serious arrhythmia was recorded. Conclusion We found in animal study that low, moderate, and high doses of sugammadex did not significantly altered corrected QT intervals and did not cause any significant arrhythmia. |
| first_indexed | 2024-04-11T05:03:29Z |
| format | Article |
| id | doaj.art-bddff3b55963468384a7e6896a548089 |
| institution | Directory Open Access Journal |
| issn | 2731-3786 |
| language | English |
| last_indexed | 2024-04-11T05:03:29Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Anesthesia, Analgesia and Critical Care |
| spelling | doaj.art-bddff3b55963468384a7e6896a5480892022-12-25T12:33:59ZengBMCJournal of Anesthesia, Analgesia and Critical Care2731-37862022-12-01211710.1186/s44158-022-00077-0Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal studyEmin Tunç Demir0Mesut Erbaş1Department of Anesthesiology and Reanimation, Intensive Care Science, Aydin State HospitalDepartment of Anesthesiology and Reanimation, Çanakkale Onsekiz Mart University Faculty of MedicineAbstract Background Studies on higher doses of sugammadex effect on QT interval and leading arrhythmia have been limited. In this study, we aimed to investigate possible proarrhythmic effect of higher doses of sugammadex in conditions that required urgent reversal of neuromuscular blockade during general anesthesia in an experimental animal model. Methods It was experimental animal study. Total of 15 male New Zealand rabbits were randomly divided into three groups for low (4 mg/kg, n = 5), moderate (16 mg/kg, n = 5), and high dose of sugammadex (32 mg/kg, n = 5). All rabbits were premedicated by intramuscular ketamine 10 mg/kg, and general anesthesia was inducted by intravenous injection of 2 mg/kg of a propofol, 1 mcg/kg fentanyl, and 0.6 mg/kg rocuronium injection. Airway was provided by V-gel rabbit and connected to anesthetic device and ventilated at about 40 cycle/min and 10 ml/kg; oxygen 50% plus air 50% mixture was used with 1 MAC isoflurane to maintain anesthesia. Electrocardiographic monitorization and arterial cannulation were provided to follow-up mean arterial pressure and for arterial blood gas analyses. Intravenous sugammadex in three different doses were injected at 25th min of induction. After observing adequate respiration of all rabbits, V-gel rabbit was removed. Parameters and ECG recordings were taken basal value before induction and at the 5th, 10th, 20th, 25th, 30th, and 40th min to measure corrected QT intervals and were stored on digital media. QT interval was calculated as the time from the beginning of the Q wave to the end of the T wave. Corrected QT interval was calculated according to the Bazett’s formula. Possible adverse effects were observed and recorded. Results In all three groups, there was no significant statistical difference in mean arterial blood gases parameters, arterial pressures, heart rates, and Bazett QTc values, and no serious arrhythmia was recorded. Conclusion We found in animal study that low, moderate, and high doses of sugammadex did not significantly altered corrected QT intervals and did not cause any significant arrhythmia.https://doi.org/10.1186/s44158-022-00077-0SugammadexQT intervalsArrhythmiaElectrocardiographyExperimental study |
| spellingShingle | Emin Tunç Demir Mesut Erbaş Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal study Journal of Anesthesia, Analgesia and Critical Care Sugammadex QT intervals Arrhythmia Electrocardiography Experimental study |
| title | Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal study |
| title_full | Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal study |
| title_fullStr | Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal study |
| title_full_unstemmed | Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal study |
| title_short | Investigation of proarrhythmic effect of high sugammadex doses: an experimental animal study |
| title_sort | investigation of proarrhythmic effect of high sugammadex doses an experimental animal study |
| topic | Sugammadex QT intervals Arrhythmia Electrocardiography Experimental study |
| url | https://doi.org/10.1186/s44158-022-00077-0 |
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