TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity
Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05167-8 |
| _version_ | 1818835077160763392 |
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| author | Paloma Riquelme Jan Haarer Anja Kammler Lisa Walter Stefan Tomiuk Norbert Ahrens Anja K. Wege Ivan Goecze Daniel Zecher Bernhard Banas Rainer Spang Fred Fändrich Manfred B. Lutz Birgit Sawitzki Hans J. Schlitt Jordi Ochando Edward K. Geissler James A. Hutchinson |
| author_facet | Paloma Riquelme Jan Haarer Anja Kammler Lisa Walter Stefan Tomiuk Norbert Ahrens Anja K. Wege Ivan Goecze Daniel Zecher Bernhard Banas Rainer Spang Fred Fändrich Manfred B. Lutz Birgit Sawitzki Hans J. Schlitt Jordi Ochando Edward K. Geissler James A. Hutchinson |
| author_sort | Paloma Riquelme |
| collection | DOAJ |
| description | Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients. |
| first_indexed | 2024-12-19T02:44:58Z |
| format | Article |
| id | doaj.art-bde1072b3b4842efb0f1df25fc4a3f9e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:44:58Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-bde1072b3b4842efb0f1df25fc4a3f9e2022-12-21T20:38:58ZengNature PortfolioNature Communications2041-17232018-07-019111810.1038/s41467-018-05167-8TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunityPaloma Riquelme0Jan Haarer1Anja Kammler2Lisa Walter3Stefan Tomiuk4Norbert Ahrens5Anja K. Wege6Ivan Goecze7Daniel Zecher8Bernhard Banas9Rainer Spang10Fred Fändrich11Manfred B. Lutz12Birgit Sawitzki13Hans J. Schlitt14Jordi Ochando15Edward K. Geissler16James A. Hutchinson17Department of Surgery, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgMiltenyi Biotec GmbHTransfusion Medicine, Institute for Clinical Chemistry, University Hospital RegensburgDepartment of Gynecology and Obstetrics, University Medical Center RegensburgDepartment of Surgery, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Nephrology, University Hospital RegensburgDepartment of Statistical Bioinformatics, Institute for Functional Genomics, University of RegensburgDepartment of Surgery, University Hospital Schleswig-HolsteinInstitute for Virology and Immunobiology, University of WürzburgInstitute for Medical Immunology, Berlin Charité University HospitalDepartment of Surgery, University Hospital RegensburgInmunología de Trasplantes, Centro Nacional de MicrobiologíaDepartment of Surgery, University Hospital RegensburgDepartment of Surgery, University Hospital RegensburgRegulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients.https://doi.org/10.1038/s41467-018-05167-8 |
| spellingShingle | Paloma Riquelme Jan Haarer Anja Kammler Lisa Walter Stefan Tomiuk Norbert Ahrens Anja K. Wege Ivan Goecze Daniel Zecher Bernhard Banas Rainer Spang Fred Fändrich Manfred B. Lutz Birgit Sawitzki Hans J. Schlitt Jordi Ochando Edward K. Geissler James A. Hutchinson TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity Nature Communications |
| title | TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity |
| title_full | TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity |
| title_fullStr | TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity |
| title_full_unstemmed | TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity |
| title_short | TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity |
| title_sort | tigit itregs elicited by human regulatory macrophages control t cell immunity |
| url | https://doi.org/10.1038/s41467-018-05167-8 |
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