Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review
Klinefelter Syndrome (KS) remains underdiagnosed due to its complex clinical presentation. Here, the authors present the case of a 48-year-old of KS complicated with Type 2 Diabetes Mellitus (DM), hypothyroidism and cryptorchidism as well as perform a literature review. The patient first visited the...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2020-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/13465/43167_CE[Ra1]_F(SHU)_PF1(AJ_SL)_PN(SL).pdf |
| _version_ | 1819162739563560960 |
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| author | Wei Zhu Shiliang Wang ShaoGang Ma Liuxue Yang Yali Qiu |
| author_facet | Wei Zhu Shiliang Wang ShaoGang Ma Liuxue Yang Yali Qiu |
| author_sort | Wei Zhu |
| collection | DOAJ |
| description | Klinefelter Syndrome (KS) remains underdiagnosed due to its complex clinical presentation. Here, the authors present the case of a 48-year-old of KS complicated with Type 2 Diabetes Mellitus (DM), hypothyroidism and cryptorchidism as well as perform a literature review. The patient first visited the hospital for diabetes. Male sexual characteristics were missing, complicated with cryptorchidism. Laboratory and chromosome tests were performed to confirm the diagnosis. The patient demonstrated low testosterone and high gonadotropin levels, with the karyotype of 47, XXY. Thus, for diabetes patients who lack male sexual characteristics, gonadal function and chromosome-related examinations should be performed for analysis and differential diagnosis. Based on existing data, there is a pressing need to generate better evidence for KS early diagnosis and comprehensive treatment. |
| first_indexed | 2024-12-22T17:33:02Z |
| format | Article |
| id | doaj.art-bde1687224e04abeb2359ad6c88e364d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-22T17:33:02Z |
| publishDate | 2020-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-bde1687224e04abeb2359ad6c88e364d2022-12-21T18:18:34ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-01-01141OD12OD1310.7860/JCDR/2020/43167.13465Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature ReviewWei Zhu0Shiliang Wang1ShaoGang Ma2Liuxue Yang3Yali Qiu4Department of Internal Medicine, Caiji Town Hospital, No. 1 Suwang Road, Suqian 223800, Jiangsu Province, China.Department of Internal Medicine, Caiji Town Hospital, No. 1 Suwang Road, Suqian 223800, Jiangsu Province, China.Department of Endocrinology and Metabolism, Suqian First Hospital, No. 120 Suzhi Road, Suqian 223800, Jiangsu Province, China.Department of Endocrinology and Metabolism, the Second Affiliated Hospital of Guilin Medical University, No. 212 Renmin Road, Lingui District, Guilin, Guangxi Zhuang Autonomous Region, China.Department of Neonatal Screening and Care, Women and Children’s Hospital of Suqian, No. 9 Ping’an Road, Suqian 223800, Jiangsu Province, China.Klinefelter Syndrome (KS) remains underdiagnosed due to its complex clinical presentation. Here, the authors present the case of a 48-year-old of KS complicated with Type 2 Diabetes Mellitus (DM), hypothyroidism and cryptorchidism as well as perform a literature review. The patient first visited the hospital for diabetes. Male sexual characteristics were missing, complicated with cryptorchidism. Laboratory and chromosome tests were performed to confirm the diagnosis. The patient demonstrated low testosterone and high gonadotropin levels, with the karyotype of 47, XXY. Thus, for diabetes patients who lack male sexual characteristics, gonadal function and chromosome-related examinations should be performed for analysis and differential diagnosis. Based on existing data, there is a pressing need to generate better evidence for KS early diagnosis and comprehensive treatment.https://jcdr.net/articles/PDF/13465/43167_CE[Ra1]_F(SHU)_PF1(AJ_SL)_PN(SL).pdfanalysiscomplicationsex chromosome |
| spellingShingle | Wei Zhu Shiliang Wang ShaoGang Ma Liuxue Yang Yali Qiu Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review Journal of Clinical and Diagnostic Research analysis complication sex chromosome |
| title | Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review |
| title_full | Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review |
| title_fullStr | Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review |
| title_full_unstemmed | Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review |
| title_short | Klinefelter Syndrome Complicated with Diabetes Mellitus, Hypothyroidism and Cryptorchidism: Case Report and Literature Review |
| title_sort | klinefelter syndrome complicated with diabetes mellitus hypothyroidism and cryptorchidism case report and literature review |
| topic | analysis complication sex chromosome |
| url | https://jcdr.net/articles/PDF/13465/43167_CE[Ra1]_F(SHU)_PF1(AJ_SL)_PN(SL).pdf |
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