Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis
Abstract Background and Aim Eosinophilic esophagitis (EoE) is a chronic disease which may progress to a fibro‐stenotic phenotype due to esophageal sub‐epithelial fibrosis. Esophageal wall thickening in patients with EoE has been demonstrated in a few studies using endoscopic ultrasound (EUS). The ai...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | JGH Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jgh3.12866 |
| _version_ | 1827980567868604416 |
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| author | Stephanie Wong Romina Safaeian Joshua Zobel Richard H Holloway Andrew Ruszkiewicz Nam Q Nguyen |
| author_facet | Stephanie Wong Romina Safaeian Joshua Zobel Richard H Holloway Andrew Ruszkiewicz Nam Q Nguyen |
| author_sort | Stephanie Wong |
| collection | DOAJ |
| description | Abstract Background and Aim Eosinophilic esophagitis (EoE) is a chronic disease which may progress to a fibro‐stenotic phenotype due to esophageal sub‐epithelial fibrosis. Esophageal wall thickening in patients with EoE has been demonstrated in a few studies using endoscopic ultrasound (EUS). The aim of this study was to longitudinally assess the endoscopic appearance, wall thickness, histology, and dysphagia score of EoE patients. Methods Patients with EoE were recruited and studied between February 2012 and April 2021. Patients were evaluated on two separate occasions at least 12 months apart with endoscopy, EUS, and esophageal mucosal biopsies. The dysphagia score and epidemiology data were also assessed. Results A total of 16 EoE patients were included with a mean follow‐up duration of 2.2 ± 1.2 years. In 14/16 (88%) patients, the total wall thickness of the distal esophagus significantly increased (P = 0.0012) as a result of thickening of the muscularis propria (P = 0.0218). However, only 1/14 (7%) patient had an increase in the dysphagia score, while 8/14 (57%) and 5/14 (36%) had a stable and reduced dysphagia score, respectively. No differences were found in the total thickness of other esophageal regions, dysphagia score, endoscopic appearance, and eosinophil count over time. Conclusion Distal esophageal wall thickness increases with time in EoE patients, independent of the dysphagia score and eosinophil count. |
| first_indexed | 2024-04-09T21:54:35Z |
| format | Article |
| id | doaj.art-bde90d16a79c484b874b3639eee6cbbe |
| institution | Directory Open Access Journal |
| issn | 2397-9070 |
| language | English |
| last_indexed | 2024-04-09T21:54:35Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | JGH Open |
| spelling | doaj.art-bde90d16a79c484b874b3639eee6cbbe2023-03-24T06:55:37ZengWileyJGH Open2397-90702023-03-017317818110.1002/jgh3.12866Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitisStephanie Wong0Romina Safaeian1Joshua Zobel2Richard H Holloway3Andrew Ruszkiewicz4Nam Q Nguyen5Department of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia AustraliaDepartment of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia AustraliaDepartment of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia AustraliaDepartment of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia AustraliaSchool of Medicine University of Adelaide Adelaide South Australia AustraliaDepartment of Gastroenterology and Hepatology Royal Adelaide Hospital Adelaide South Australia AustraliaAbstract Background and Aim Eosinophilic esophagitis (EoE) is a chronic disease which may progress to a fibro‐stenotic phenotype due to esophageal sub‐epithelial fibrosis. Esophageal wall thickening in patients with EoE has been demonstrated in a few studies using endoscopic ultrasound (EUS). The aim of this study was to longitudinally assess the endoscopic appearance, wall thickness, histology, and dysphagia score of EoE patients. Methods Patients with EoE were recruited and studied between February 2012 and April 2021. Patients were evaluated on two separate occasions at least 12 months apart with endoscopy, EUS, and esophageal mucosal biopsies. The dysphagia score and epidemiology data were also assessed. Results A total of 16 EoE patients were included with a mean follow‐up duration of 2.2 ± 1.2 years. In 14/16 (88%) patients, the total wall thickness of the distal esophagus significantly increased (P = 0.0012) as a result of thickening of the muscularis propria (P = 0.0218). However, only 1/14 (7%) patient had an increase in the dysphagia score, while 8/14 (57%) and 5/14 (36%) had a stable and reduced dysphagia score, respectively. No differences were found in the total thickness of other esophageal regions, dysphagia score, endoscopic appearance, and eosinophil count over time. Conclusion Distal esophageal wall thickness increases with time in EoE patients, independent of the dysphagia score and eosinophil count.https://doi.org/10.1002/jgh3.12866dysphagiaendoscopic ultrasoundeosinophil counteosinophilic esophagitisesophageal wall thickness |
| spellingShingle | Stephanie Wong Romina Safaeian Joshua Zobel Richard H Holloway Andrew Ruszkiewicz Nam Q Nguyen Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis JGH Open dysphagia endoscopic ultrasound eosinophil count eosinophilic esophagitis esophageal wall thickness |
| title | Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis |
| title_full | Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis |
| title_fullStr | Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis |
| title_full_unstemmed | Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis |
| title_short | Increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis |
| title_sort | increase in distal esophageal wall thickness with time in adult patients with eosinophilic esophagitis |
| topic | dysphagia endoscopic ultrasound eosinophil count eosinophilic esophagitis esophageal wall thickness |
| url | https://doi.org/10.1002/jgh3.12866 |
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