An assessment of microvascular hemodynamics in human macula
Abstract An adequate blood supply to meet the energy demands is essential for any tissue, particularly for high energy demand tissues such as the retina. A critical question is: How is the dynamic match between neuronal demands and blood supply achieved? We present a quantitative assessment of tempo...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-33490-8 |
| _version_ | 1797827531429117952 |
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| author | Dao-Yi Yu Andrew Mehnert Chandrakumar Balaratnasingam Paula K. Yu Martin Hein Dong An Stephen J. Cringle |
| author_facet | Dao-Yi Yu Andrew Mehnert Chandrakumar Balaratnasingam Paula K. Yu Martin Hein Dong An Stephen J. Cringle |
| author_sort | Dao-Yi Yu |
| collection | DOAJ |
| description | Abstract An adequate blood supply to meet the energy demands is essential for any tissue, particularly for high energy demand tissues such as the retina. A critical question is: How is the dynamic match between neuronal demands and blood supply achieved? We present a quantitative assessment of temporal and spatial variations in perfusion in the macular capillary network in 10 healthy human subjects using a non-invasive and label-free imaging technique. The assessment is based on the calculation of the coefficient of variation (CoV) of the perfusion signal from arterioles, venules and capillaries from a sequence of optical coherence tomography angiography images centred on the fovea. Significant heterogeneity of the spatial and temporal variation was found within arterioles, venules and capillary networks. The CoV values of the capillaries and smallest vessels were significantly higher than that in the larger vessels. Our results demonstrate the presence of significant heterogeneity of spatial and temporal variation within each element of the macular microvasculature, particularly in the capillaries and finer vessels. Our findings suggest that the dynamic match between neuronal demands and blood supply is achieved by frequent alteration of local blood flow evidenced by capillary perfusion variations both spatially and temporally in the macular region. |
| first_indexed | 2024-04-09T12:49:49Z |
| format | Article |
| id | doaj.art-bde91aae77a0432696fa608cdf78aab7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T12:49:49Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-bde91aae77a0432696fa608cdf78aab72023-05-14T11:17:02ZengNature PortfolioScientific Reports2045-23222023-05-0113111710.1038/s41598-023-33490-8An assessment of microvascular hemodynamics in human maculaDao-Yi Yu0Andrew Mehnert1Chandrakumar Balaratnasingam2Paula K. Yu3Martin Hein4Dong An5Stephen J. Cringle6Centre for Ophthalmology and Visual Science, The University of Western AustraliaCentre for Ophthalmology and Visual Science, The University of Western AustraliaCentre for Ophthalmology and Visual Science, The University of Western AustraliaCentre for Ophthalmology and Visual Science, The University of Western AustraliaCentre for Ophthalmology and Visual Science, The University of Western AustraliaCentre for Ophthalmology and Visual Science, The University of Western AustraliaCentre for Ophthalmology and Visual Science, The University of Western AustraliaAbstract An adequate blood supply to meet the energy demands is essential for any tissue, particularly for high energy demand tissues such as the retina. A critical question is: How is the dynamic match between neuronal demands and blood supply achieved? We present a quantitative assessment of temporal and spatial variations in perfusion in the macular capillary network in 10 healthy human subjects using a non-invasive and label-free imaging technique. The assessment is based on the calculation of the coefficient of variation (CoV) of the perfusion signal from arterioles, venules and capillaries from a sequence of optical coherence tomography angiography images centred on the fovea. Significant heterogeneity of the spatial and temporal variation was found within arterioles, venules and capillary networks. The CoV values of the capillaries and smallest vessels were significantly higher than that in the larger vessels. Our results demonstrate the presence of significant heterogeneity of spatial and temporal variation within each element of the macular microvasculature, particularly in the capillaries and finer vessels. Our findings suggest that the dynamic match between neuronal demands and blood supply is achieved by frequent alteration of local blood flow evidenced by capillary perfusion variations both spatially and temporally in the macular region.https://doi.org/10.1038/s41598-023-33490-8 |
| spellingShingle | Dao-Yi Yu Andrew Mehnert Chandrakumar Balaratnasingam Paula K. Yu Martin Hein Dong An Stephen J. Cringle An assessment of microvascular hemodynamics in human macula Scientific Reports |
| title | An assessment of microvascular hemodynamics in human macula |
| title_full | An assessment of microvascular hemodynamics in human macula |
| title_fullStr | An assessment of microvascular hemodynamics in human macula |
| title_full_unstemmed | An assessment of microvascular hemodynamics in human macula |
| title_short | An assessment of microvascular hemodynamics in human macula |
| title_sort | assessment of microvascular hemodynamics in human macula |
| url | https://doi.org/10.1038/s41598-023-33490-8 |
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