Total neoadjuvant treatment in locally advanced rectal cancer
Locally advanced rectal cancer requires a multidisciplinary management, traditionally based on neo-adjuvant (chemo) radiotherapy, conservative surgery with total mesorectal excision and adjuvant chemotherapy. Despite effective in term of local control, this strategy is linked to a high risk of dista...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-05-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S193652332100036X |
| _version_ | 1818853830975029248 |
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| author | Francesca De Felice Vincenzo Tombolini Enrico Cortesi |
| author_facet | Francesca De Felice Vincenzo Tombolini Enrico Cortesi |
| author_sort | Francesca De Felice |
| collection | DOAJ |
| description | Locally advanced rectal cancer requires a multidisciplinary management, traditionally based on neo-adjuvant (chemo) radiotherapy, conservative surgery with total mesorectal excision and adjuvant chemotherapy. Despite effective in term of local control, this strategy is linked to a high risk of distant metastasis (up to 30%). In this context, recent published randomized phase III clinical trials have tested the potential benefits with a different sequencing and/or intensification of the standard components of the trimodal therapy.Here, we briefly assess the efficacy and discuss the clinical relevance of total neoadjuvant treatment with a focus on indications and results in the short-course radiotherapy followed by chemotherapy use for this setting of patients. Long term results and additional prospective studies are necessary to more accurately estimate the clinical benefit and further establish the role of total neoadjuvant therapy in locally advanced rectal cancer disease. |
| first_indexed | 2024-12-19T07:43:03Z |
| format | Article |
| id | doaj.art-bdeafd3bf7424337b418bc99c4512c06 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-12-19T07:43:03Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-bdeafd3bf7424337b418bc99c4512c062022-12-21T20:30:25ZengElsevierTranslational Oncology1936-52332021-05-01145101044Total neoadjuvant treatment in locally advanced rectal cancerFrancesca De Felice0Vincenzo Tombolini1Enrico Cortesi2Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Viale Regina Elena 326, 00161 Rome, Italy; Corresponding author.Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Viale Regina Elena 326, 00161 Rome, ItalyMedical Oncology Department, Policlinico Umberto I, “Sapienza” University of Rome, ItalyLocally advanced rectal cancer requires a multidisciplinary management, traditionally based on neo-adjuvant (chemo) radiotherapy, conservative surgery with total mesorectal excision and adjuvant chemotherapy. Despite effective in term of local control, this strategy is linked to a high risk of distant metastasis (up to 30%). In this context, recent published randomized phase III clinical trials have tested the potential benefits with a different sequencing and/or intensification of the standard components of the trimodal therapy.Here, we briefly assess the efficacy and discuss the clinical relevance of total neoadjuvant treatment with a focus on indications and results in the short-course radiotherapy followed by chemotherapy use for this setting of patients. Long term results and additional prospective studies are necessary to more accurately estimate the clinical benefit and further establish the role of total neoadjuvant therapy in locally advanced rectal cancer disease.http://www.sciencedirect.com/science/article/pii/S193652332100036XRectal cancerBRAFChemotherapyRadiotherapySurgery |
| spellingShingle | Francesca De Felice Vincenzo Tombolini Enrico Cortesi Total neoadjuvant treatment in locally advanced rectal cancer Translational Oncology Rectal cancer BRAF Chemotherapy Radiotherapy Surgery |
| title | Total neoadjuvant treatment in locally advanced rectal cancer |
| title_full | Total neoadjuvant treatment in locally advanced rectal cancer |
| title_fullStr | Total neoadjuvant treatment in locally advanced rectal cancer |
| title_full_unstemmed | Total neoadjuvant treatment in locally advanced rectal cancer |
| title_short | Total neoadjuvant treatment in locally advanced rectal cancer |
| title_sort | total neoadjuvant treatment in locally advanced rectal cancer |
| topic | Rectal cancer BRAF Chemotherapy Radiotherapy Surgery |
| url | http://www.sciencedirect.com/science/article/pii/S193652332100036X |
| work_keys_str_mv | AT francescadefelice totalneoadjuvanttreatmentinlocallyadvancedrectalcancer AT vincenzotombolini totalneoadjuvanttreatmentinlocallyadvancedrectalcancer AT enricocortesi totalneoadjuvanttreatmentinlocallyadvancedrectalcancer |