Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases
Admixed populations arise when two or more ancestral populations interbreed. As a result of this admixture, the genome of admixed populations is defined by tracts of variable size inherited from these parental groups and has particular genetic features that provide valuable information about their d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/6962 |
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| author | Eva Suarez-Pajes Ana Díaz-de Usera Itahisa Marcelino-Rodríguez Beatriz Guillen-Guio Carlos Flores |
| author_facet | Eva Suarez-Pajes Ana Díaz-de Usera Itahisa Marcelino-Rodríguez Beatriz Guillen-Guio Carlos Flores |
| author_sort | Eva Suarez-Pajes |
| collection | DOAJ |
| description | Admixed populations arise when two or more ancestral populations interbreed. As a result of this admixture, the genome of admixed populations is defined by tracts of variable size inherited from these parental groups and has particular genetic features that provide valuable information about their demographic history. Diverse methods can be used to derive the ancestry apportionment of admixed individuals, and such inferences can be leveraged for the discovery of genetic loci associated with diseases and traits, therefore having important biomedical implications. In this review article, we summarize the most common methods of global and local genetic ancestry estimation and discuss the use of admixture mapping studies in human diseases. |
| first_indexed | 2024-03-10T09:59:57Z |
| format | Article |
| id | doaj.art-bdec4299641f4b239e845f39ec867cb8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:59:57Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-bdec4299641f4b239e845f39ec867cb82023-11-22T02:03:49ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213696210.3390/ijms22136962Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human DiseasesEva Suarez-Pajes0Ana Díaz-de Usera1Itahisa Marcelino-Rodríguez2Beatriz Guillen-Guio3Carlos Flores4Research Unit, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainGenomics Division, Instituto Tecnológico y de Energías Renovables (ITER), 38600 Santa Cruz de Tenerife, SpainResearch Unit, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainResearch Unit, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainResearch Unit, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, SpainAdmixed populations arise when two or more ancestral populations interbreed. As a result of this admixture, the genome of admixed populations is defined by tracts of variable size inherited from these parental groups and has particular genetic features that provide valuable information about their demographic history. Diverse methods can be used to derive the ancestry apportionment of admixed individuals, and such inferences can be leveraged for the discovery of genetic loci associated with diseases and traits, therefore having important biomedical implications. In this review article, we summarize the most common methods of global and local genetic ancestry estimation and discuss the use of admixture mapping studies in human diseases.https://www.mdpi.com/1422-0067/22/13/6962admixture mappinggenetic ancestryancestry informative markersnext-generation sequencing |
| spellingShingle | Eva Suarez-Pajes Ana Díaz-de Usera Itahisa Marcelino-Rodríguez Beatriz Guillen-Guio Carlos Flores Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases International Journal of Molecular Sciences admixture mapping genetic ancestry ancestry informative markers next-generation sequencing |
| title | Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases |
| title_full | Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases |
| title_fullStr | Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases |
| title_full_unstemmed | Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases |
| title_short | Genetic Ancestry Inference and Its Application for the Genetic Mapping of Human Diseases |
| title_sort | genetic ancestry inference and its application for the genetic mapping of human diseases |
| topic | admixture mapping genetic ancestry ancestry informative markers next-generation sequencing |
| url | https://www.mdpi.com/1422-0067/22/13/6962 |
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