Gene Editing Technologies to Target HBV cccDNA

Gene Editing Technologies to Target HBV cccDNA

Hepatitis B virus (HBV) remains a significant cause of mortality and morbidity worldwide, since chronic HBV infection is associated with elevated risk of cirrhosis and hepatocellular carcinoma. Current licensed therapies against HBV efficiently suppress viral replication; however, they do not have s...

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Bibliographic Details
Main Authors: Maria Guadalupe Martinez, Elena Smekalova, Emmanuel Combe, Francine Gregoire, Fabien Zoulim, Barbara Testoni
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Viruses
Subjects:
hepatitis B virus
HBV
cccDNA
gene editing
meganuclease
TALEN
Online Access:https://www.mdpi.com/1999-4915/14/12/2654

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