A Novel Composite Voltammetric Sensor Based on Yttria-Stabilized Zirconia Doped with Neodymium-Carbon Black-Nafion Glassy Carbon Electrode for Metoprolol Determination
For the first time, a new composite voltammetric sensor based on yttria-stabilized zirconia doped with neodymium-carbon black-Nafion glassy carbon electrode (YSZNd-CB-Nafion/GCE) for the determination of metoprolol (MET) has been developed. The instrumental parameters and supporting electrolyte were...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/13/12/890 |
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| author | Małgorzata Suchanek Beata Paczosa-Bator Robert Piech |
| author_facet | Małgorzata Suchanek Beata Paczosa-Bator Robert Piech |
| author_sort | Małgorzata Suchanek |
| collection | DOAJ |
| description | For the first time, a new composite voltammetric sensor based on yttria-stabilized zirconia doped with neodymium-carbon black-Nafion glassy carbon electrode (YSZNd-CB-Nafion/GCE) for the determination of metoprolol (MET) has been developed. The instrumental parameters and supporting electrolyte were optimized. For 105 s accumulation time, linearity was achieved in the range of 0.01 to 0.2 µM. The limit of detection (for 105 s accumulation time) was equal to 2.9 nM (2 µg/L), and was the best result in comparison to other voltametric sensors. The reproducibility of the metoprolol signal presented as relative standard deviation (RSD) was equal to 1.9% (<i>n</i> = 7). Additionally, our electrode is characterized by high stability, is easy to use, and has a short preparation time. The proposed sensor was found useful for MET determination in plasma and urine, as well as for pharmaceutical samples, with a good recovery parameter (96–108%). Flow injection analysis (FIA) with amperometric detection was also performed for MET determination. The recovery was calculated and was in the range 101–103%, suggesting that the proposed material may be applied in flow injection analysis. |
| first_indexed | 2024-03-08T20:33:05Z |
| format | Article |
| id | doaj.art-bdee3ee3677e4473abeaa131151332ea |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-08T20:33:05Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-bdee3ee3677e4473abeaa131151332ea2023-12-22T14:24:16ZengMDPI AGMembranes2077-03752023-11-01131289010.3390/membranes13120890A Novel Composite Voltammetric Sensor Based on Yttria-Stabilized Zirconia Doped with Neodymium-Carbon Black-Nafion Glassy Carbon Electrode for Metoprolol DeterminationMałgorzata Suchanek0Beata Paczosa-Bator1Robert Piech2Department of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Krakow, Al. A. Mickiewicza, 30-059 Krakow, PolandDepartment of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Krakow, Al. A. Mickiewicza, 30-059 Krakow, PolandDepartment of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Krakow, Al. A. Mickiewicza, 30-059 Krakow, PolandFor the first time, a new composite voltammetric sensor based on yttria-stabilized zirconia doped with neodymium-carbon black-Nafion glassy carbon electrode (YSZNd-CB-Nafion/GCE) for the determination of metoprolol (MET) has been developed. The instrumental parameters and supporting electrolyte were optimized. For 105 s accumulation time, linearity was achieved in the range of 0.01 to 0.2 µM. The limit of detection (for 105 s accumulation time) was equal to 2.9 nM (2 µg/L), and was the best result in comparison to other voltametric sensors. The reproducibility of the metoprolol signal presented as relative standard deviation (RSD) was equal to 1.9% (<i>n</i> = 7). Additionally, our electrode is characterized by high stability, is easy to use, and has a short preparation time. The proposed sensor was found useful for MET determination in plasma and urine, as well as for pharmaceutical samples, with a good recovery parameter (96–108%). Flow injection analysis (FIA) with amperometric detection was also performed for MET determination. The recovery was calculated and was in the range 101–103%, suggesting that the proposed material may be applied in flow injection analysis.https://www.mdpi.com/2077-0375/13/12/890metoprololyttria-stabilized zirconia doped with neodymiumvoltammetryflow injection analysispharmaceutical formulation |
| spellingShingle | Małgorzata Suchanek Beata Paczosa-Bator Robert Piech A Novel Composite Voltammetric Sensor Based on Yttria-Stabilized Zirconia Doped with Neodymium-Carbon Black-Nafion Glassy Carbon Electrode for Metoprolol Determination Membranes metoprolol yttria-stabilized zirconia doped with neodymium voltammetry flow injection analysis pharmaceutical formulation |
| title | A Novel Composite Voltammetric Sensor Based on Yttria-Stabilized Zirconia Doped with Neodymium-Carbon Black-Nafion Glassy Carbon Electrode for Metoprolol Determination |
| title_full | A Novel Composite Voltammetric Sensor Based on Yttria-Stabilized Zirconia Doped with Neodymium-Carbon Black-Nafion Glassy Carbon Electrode for Metoprolol Determination |
| title_fullStr | A Novel Composite Voltammetric Sensor Based on Yttria-Stabilized Zirconia Doped with Neodymium-Carbon Black-Nafion Glassy Carbon Electrode for Metoprolol Determination |
| title_full_unstemmed | A Novel Composite Voltammetric Sensor Based on Yttria-Stabilized Zirconia Doped with Neodymium-Carbon Black-Nafion Glassy Carbon Electrode for Metoprolol Determination |
| title_short | A Novel Composite Voltammetric Sensor Based on Yttria-Stabilized Zirconia Doped with Neodymium-Carbon Black-Nafion Glassy Carbon Electrode for Metoprolol Determination |
| title_sort | novel composite voltammetric sensor based on yttria stabilized zirconia doped with neodymium carbon black nafion glassy carbon electrode for metoprolol determination |
| topic | metoprolol yttria-stabilized zirconia doped with neodymium voltammetry flow injection analysis pharmaceutical formulation |
| url | https://www.mdpi.com/2077-0375/13/12/890 |
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