Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis
Background: Calcium uptake research has a long history. However, the mitochondrial calcium uniporter (MCU) protein was first discovered in 2011. As investigations of mitochondrial calcium uniporter represent a new research hotspot, a comprehensive and objective perspective of the field is lacking. H...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1107328/full |
| _version_ | 1797947009086259200 |
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| author | Deng Pan Deng Pan Deng Pan Lin Xu Dazhuo Shi Dazhuo Shi Ming Guo Ming Guo |
| author_facet | Deng Pan Deng Pan Deng Pan Lin Xu Dazhuo Shi Dazhuo Shi Ming Guo Ming Guo |
| author_sort | Deng Pan |
| collection | DOAJ |
| description | Background: Calcium uptake research has a long history. However, the mitochondrial calcium uniporter (MCU) protein was first discovered in 2011. As investigations of mitochondrial calcium uniporter represent a new research hotspot, a comprehensive and objective perspective of the field is lacking. Hence, this bibliometric analysis aimed to provide the current study status and trends related to mitochondrial calcium uniporter research in the past decade.Methods: Articles were acquired from the Web of Science Core Collection database. We quantified and visualized information regarding annual publications, journals, cocited journals, countries/regions, institutions, authors, and cocited authors by using CiteSpace 5.8. R3 and VOSviewer. In addition, we analysed the citation and keyword bursts related to mitochondrial calcium uniporter studies.Results: From 2011 to 2022, 1,030 articles were published by 5,050 authors from 1,145 affiliations and 62 countries or regions. The country with the most published articles was the United States. The institution with the most published articles was the University of Padua. Rosario Rizzuto published the most articles and was also the most cocited author. Cell Calcium published the largest number of articles, whereas Journal of Biological Chemistry had the most cocitations. The top 5 keywords related to pathological processes were oxidative stress, cell death, permeability transition, apoptosis, and metabolism. MICU1, calcium, ryanodine receptor, ATP synthase and cyclophilin D were the top 5 keywords related to molecules.Conclusion: mitochondrial calcium uniporter research has grown stably over the last decade. Current studies focus on the structure of the mitochondrial calcium uniporter complex and its regulatory effect on mitochondrial calcium homeostasis. In addition, the potential role of mitochondrial calcium uniporter in different diseases has been explored. Current studies mostly involve investigations of cancer and neurodegenerative diseases. Our analysis provides guidance and new insights into further mitochondrial calcium uniporter research. |
| first_indexed | 2024-04-10T21:21:03Z |
| format | Article |
| id | doaj.art-bdf0dcff367642d0b9a8abc2b53be2d4 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T21:21:03Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-bdf0dcff367642d0b9a8abc2b53be2d42023-01-20T05:32:01ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-01-011410.3389/fphys.2023.11073281107328Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysisDeng Pan0Deng Pan1Deng Pan2Lin Xu3Dazhuo Shi4Dazhuo Shi5Ming Guo6Ming Guo7Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaNational Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaGynecological Department of Traditional Chinese Medicine, China-Japan Friendship Hospital, Beijing, ChinaXiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaNational Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaXiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaNational Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, ChinaBackground: Calcium uptake research has a long history. However, the mitochondrial calcium uniporter (MCU) protein was first discovered in 2011. As investigations of mitochondrial calcium uniporter represent a new research hotspot, a comprehensive and objective perspective of the field is lacking. Hence, this bibliometric analysis aimed to provide the current study status and trends related to mitochondrial calcium uniporter research in the past decade.Methods: Articles were acquired from the Web of Science Core Collection database. We quantified and visualized information regarding annual publications, journals, cocited journals, countries/regions, institutions, authors, and cocited authors by using CiteSpace 5.8. R3 and VOSviewer. In addition, we analysed the citation and keyword bursts related to mitochondrial calcium uniporter studies.Results: From 2011 to 2022, 1,030 articles were published by 5,050 authors from 1,145 affiliations and 62 countries or regions. The country with the most published articles was the United States. The institution with the most published articles was the University of Padua. Rosario Rizzuto published the most articles and was also the most cocited author. Cell Calcium published the largest number of articles, whereas Journal of Biological Chemistry had the most cocitations. The top 5 keywords related to pathological processes were oxidative stress, cell death, permeability transition, apoptosis, and metabolism. MICU1, calcium, ryanodine receptor, ATP synthase and cyclophilin D were the top 5 keywords related to molecules.Conclusion: mitochondrial calcium uniporter research has grown stably over the last decade. Current studies focus on the structure of the mitochondrial calcium uniporter complex and its regulatory effect on mitochondrial calcium homeostasis. In addition, the potential role of mitochondrial calcium uniporter in different diseases has been explored. Current studies mostly involve investigations of cancer and neurodegenerative diseases. Our analysis provides guidance and new insights into further mitochondrial calcium uniporter research.https://www.frontiersin.org/articles/10.3389/fphys.2023.1107328/fullmitochondrial calcium uniportercalcium homeostasiscitespaceVOSviewerbibliometric |
| spellingShingle | Deng Pan Deng Pan Deng Pan Lin Xu Dazhuo Shi Dazhuo Shi Ming Guo Ming Guo Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis Frontiers in Physiology mitochondrial calcium uniporter calcium homeostasis citespace VOSviewer bibliometric |
| title | Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis |
| title_full | Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis |
| title_fullStr | Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis |
| title_full_unstemmed | Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis |
| title_short | Knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022: A bibliometric analysis |
| title_sort | knowledge mapping of mitochondrial calcium uniporter from 2011 to 2022 a bibliometric analysis |
| topic | mitochondrial calcium uniporter calcium homeostasis citespace VOSviewer bibliometric |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1107328/full |
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