Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies
Colorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which has unfortunately missed an opportunity for surgery; therefore, elucidation of the crucial pathways of CRC development and discovery of targe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1007509/full |
| _version_ | 1811209701434589184 |
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| author | Liming Qiang Hongpeng Li Zhaohui Wang Lin Wan Guangfu Jiang |
| author_facet | Liming Qiang Hongpeng Li Zhaohui Wang Lin Wan Guangfu Jiang |
| author_sort | Liming Qiang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which has unfortunately missed an opportunity for surgery; therefore, elucidation of the crucial pathways of CRC development and discovery of targeted therapeutic strategies should be anticipated. Autophagy, which is an evolutionarily highly conserved catabolic process, may promote tumorigenesis and development of CRC. On the contrary, autophagy can trigger programmed cell death to inhibit CRC progression. Correspondingly, several targeted therapeutic strategies have been reported in CRC, including small-molecule compounds, polypeptides, non-coding RNAs, photodynamic, and adjuvant therapies. Thus, in this review, we focus on summarizing the crucial pathways of autophagy in CRC, and further discuss the current therapeutic strategies targeting autophagy. Together, these findings may shed light on the key regulatory mechanisms of autophagy and provide more promising therapeutic approaches for the future CRC therapies. |
| first_indexed | 2024-04-12T04:43:55Z |
| format | Article |
| id | doaj.art-bdf280be0df24ff0bf68caa496aa562e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T04:43:55Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-bdf280be0df24ff0bf68caa496aa562e2022-12-22T03:47:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.10075091007509Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapiesLiming Qiang0Hongpeng Li1Zhaohui Wang2Lin Wan3Guangfu Jiang4Department of Gastroenterology Ward, Guang’an People’s Hospital, Guang’an, ChinaDepartment of Gastrointestinal Surgery, Guang’an People’s Hospital, Guang’an, ChinaDepartment of Gastrointestinal Surgery, Guang’an People’s Hospital, Guang’an, ChinaDepartment of Gastrointestinal Surgery, Guang’an People’s Hospital, Guang’an, ChinaDepartment of Gastrointestinal Surgery, Guang’an People’s Hospital, Guang’an, ChinaColorectal cancer (CRC) is a common gastrointestinal tumor with a high degree of malignancy, and most clinical cases are diagnosed at an advanced stage, which has unfortunately missed an opportunity for surgery; therefore, elucidation of the crucial pathways of CRC development and discovery of targeted therapeutic strategies should be anticipated. Autophagy, which is an evolutionarily highly conserved catabolic process, may promote tumorigenesis and development of CRC. On the contrary, autophagy can trigger programmed cell death to inhibit CRC progression. Correspondingly, several targeted therapeutic strategies have been reported in CRC, including small-molecule compounds, polypeptides, non-coding RNAs, photodynamic, and adjuvant therapies. Thus, in this review, we focus on summarizing the crucial pathways of autophagy in CRC, and further discuss the current therapeutic strategies targeting autophagy. Together, these findings may shed light on the key regulatory mechanisms of autophagy and provide more promising therapeutic approaches for the future CRC therapies.https://www.frontiersin.org/articles/10.3389/fonc.2022.1007509/fullcolorectal cancer (CRC)autophagycrucial pathwaytherapeutic strategytargeted therapy |
| spellingShingle | Liming Qiang Hongpeng Li Zhaohui Wang Lin Wan Guangfu Jiang Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies Frontiers in Oncology colorectal cancer (CRC) autophagy crucial pathway therapeutic strategy targeted therapy |
| title | Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies |
| title_full | Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies |
| title_fullStr | Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies |
| title_full_unstemmed | Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies |
| title_short | Deconvoluting the complexity of autophagy in colorectal cancer: From crucial pathways to targeted therapies |
| title_sort | deconvoluting the complexity of autophagy in colorectal cancer from crucial pathways to targeted therapies |
| topic | colorectal cancer (CRC) autophagy crucial pathway therapeutic strategy targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1007509/full |
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