Attention‐deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta‐analysis
Abstract Attention‐deficit/hyperactivity disorder (ADHD) often co‐occurs with other psychiatric and physical diseases. However, available evidence on associations between ADHD and cardiovascular diseases (CVDs) is mixed. To systematically review, quantitatively synthesize, and appraise available evi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | JCPP Advances |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcv2.12158 |
| _version_ | 1797685526784901120 |
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| author | Lin Li Honghui Yao Le Zhang Miguel Garcia‐Argibay Ebba Du Rietz Isabell Brikell Marco Solmi Samuele Cortese J. Antoni Ramos‐Quiroga Marta Ribasés Zheng Chang Henrik Larsson |
| author_facet | Lin Li Honghui Yao Le Zhang Miguel Garcia‐Argibay Ebba Du Rietz Isabell Brikell Marco Solmi Samuele Cortese J. Antoni Ramos‐Quiroga Marta Ribasés Zheng Chang Henrik Larsson |
| author_sort | Lin Li |
| collection | DOAJ |
| description | Abstract Attention‐deficit/hyperactivity disorder (ADHD) often co‐occurs with other psychiatric and physical diseases. However, available evidence on associations between ADHD and cardiovascular diseases (CVDs) is mixed. To systematically review, quantitatively synthesize, and appraise available evidence on the link between ADHD with CVDs, we searched relevant articles in PubMed, Embase, PsycINFO, and Web of Science from inception to May 1, 2022. Study quality was assessed by using the Newcastle‐Ottawa Scale, and random‐effects model meta‐analyses were performed. A total of 18,391,169 (ADHD: n = 421,224) individuals from 11 studies were included in our systematic review and 8,196,648 (ADHD = 332,619) individuals from five studies were included in the main meta‐analysis of adjusted estimates. Pooled estimates showed that ADHD was significantly associated with an increased risk of CVDs in analyses based on adjusted effect size (odds ratio (OR) = 1.96; 95% confidence interval (CI) = 1.19–2.23, Q = 140.74, PQ < 0.001, I2 = 97.2%). When restricted among adults, the heterogeneity declined to null (OR = 1.73; 95% CI = 1.14–2.62, Q = 6.28, PQ = 0.10, I2 = 6.28%), suggesting age might be the main source of heterogeneity. In subgroup analyses, we found increased risk of CVDs associated with ADHD across age groups, type of CVDs, and data sources. This systematic review and meta‐analyses indicate that ADHD is associated with increased risk for CVDs, but further studies with various study designs are warranted to advance the understanding of the underlying mechanisms for the observed association between ADHD and CVDs. Additional research is also needed to resolve the role of ADHD medications which remains unclear due to the limited number of primary studies exploring this issue. |
| first_indexed | 2024-03-12T00:45:27Z |
| format | Article |
| id | doaj.art-bdf2b3b48e2f4f9d9e2e1b62aa213332 |
| institution | Directory Open Access Journal |
| issn | 2692-9384 |
| language | English |
| last_indexed | 2024-03-12T00:45:27Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | JCPP Advances |
| spelling | doaj.art-bdf2b3b48e2f4f9d9e2e1b62aa2133322023-09-14T18:26:40ZengWileyJCPP Advances2692-93842023-09-0133n/an/a10.1002/jcv2.12158Attention‐deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta‐analysisLin Li0Honghui Yao1Le Zhang2Miguel Garcia‐Argibay3Ebba Du Rietz4Isabell Brikell5Marco Solmi6Samuele Cortese7J. Antoni Ramos‐Quiroga8Marta Ribasés9Zheng Chang10Henrik Larsson11School of Medical Sciences Örebro University Örebro SwedenDepartment of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm SwedenDepartment of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm SwedenSchool of Medical Sciences Örebro University Örebro SwedenDepartment of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm SwedenDepartment of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm SwedenDepartment of Psychiatry University of Ottawa Ottawa Ontario CanadaCentre for Innovation in Mental Health‐Developmental Lab School of Psychology University of Southampton Southampton UKDepartment of Psychiatry and Forensic Medicine Universitat Autònoma de Barcelona Barcelona SpainBiomedical Network Research Centre on Mental Health (CIBERSAM) Madrid SpainDepartment of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm SwedenSchool of Medical Sciences Örebro University Örebro SwedenAbstract Attention‐deficit/hyperactivity disorder (ADHD) often co‐occurs with other psychiatric and physical diseases. However, available evidence on associations between ADHD and cardiovascular diseases (CVDs) is mixed. To systematically review, quantitatively synthesize, and appraise available evidence on the link between ADHD with CVDs, we searched relevant articles in PubMed, Embase, PsycINFO, and Web of Science from inception to May 1, 2022. Study quality was assessed by using the Newcastle‐Ottawa Scale, and random‐effects model meta‐analyses were performed. A total of 18,391,169 (ADHD: n = 421,224) individuals from 11 studies were included in our systematic review and 8,196,648 (ADHD = 332,619) individuals from five studies were included in the main meta‐analysis of adjusted estimates. Pooled estimates showed that ADHD was significantly associated with an increased risk of CVDs in analyses based on adjusted effect size (odds ratio (OR) = 1.96; 95% confidence interval (CI) = 1.19–2.23, Q = 140.74, PQ < 0.001, I2 = 97.2%). When restricted among adults, the heterogeneity declined to null (OR = 1.73; 95% CI = 1.14–2.62, Q = 6.28, PQ = 0.10, I2 = 6.28%), suggesting age might be the main source of heterogeneity. In subgroup analyses, we found increased risk of CVDs associated with ADHD across age groups, type of CVDs, and data sources. This systematic review and meta‐analyses indicate that ADHD is associated with increased risk for CVDs, but further studies with various study designs are warranted to advance the understanding of the underlying mechanisms for the observed association between ADHD and CVDs. Additional research is also needed to resolve the role of ADHD medications which remains unclear due to the limited number of primary studies exploring this issue.https://doi.org/10.1002/jcv2.12158attention‐deficit/hyperactivity disordercardiovascular diseasesmeta‐analysisobservational studiessystematic review |
| spellingShingle | Lin Li Honghui Yao Le Zhang Miguel Garcia‐Argibay Ebba Du Rietz Isabell Brikell Marco Solmi Samuele Cortese J. Antoni Ramos‐Quiroga Marta Ribasés Zheng Chang Henrik Larsson Attention‐deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta‐analysis JCPP Advances attention‐deficit/hyperactivity disorder cardiovascular diseases meta‐analysis observational studies systematic review |
| title | Attention‐deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta‐analysis |
| title_full | Attention‐deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta‐analysis |
| title_fullStr | Attention‐deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta‐analysis |
| title_full_unstemmed | Attention‐deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta‐analysis |
| title_short | Attention‐deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta‐analysis |
| title_sort | attention deficit hyperactivity disorder is associated with increased risk of cardiovascular diseases a systematic review and meta analysis |
| topic | attention‐deficit/hyperactivity disorder cardiovascular diseases meta‐analysis observational studies systematic review |
| url | https://doi.org/10.1002/jcv2.12158 |
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