Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway

Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway

Abstract Background Advanced prostate cancer (PCa) will develop into castration-resistant prostate cancer (CRPC) and lead to poor prognosis. As the primary subtype of CRPC, CRPC-AR accounts for the major induction of PCa heterogeneity. CRPC-AR is mainly driven by 25 transcription factors (TFs), whic...

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Bibliographic Details
Main Authors: Maozhang Li, Guangwei Bai, Yi Cen, Qitong Xie, Jiahong Chen, Jia Chen, Qingbiao Chen, Weide Zhong, Xiaobo Zhou
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Translational Medicine
Subjects:
Prostate cancer
HOXC13
cGAS/STING/IRF3 pathway
IFN-β
Immune infiltration
Online Access:https://doi.org/10.1186/s12967-023-04743-x

Internet

https://doi.org/10.1186/s12967-023-04743-x

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