Discovery of Novel Druggable Sites on Zika Virus NS3 Helicase Using X-ray Crystallography-Based Fragment Screening

Discovery of Novel Druggable Sites on Zika Virus NS3 Helicase Using X-ray Crystallography-Based Fragment Screening

The flavivirus family contains several important human pathogens, such as Zika virus (ZIKV), dengue, West Nile, and Yellow Fever viruses, that collectively lead to a large, global disease burden. Currently, there are no approved medicines that can target these viruses. The sudden outbreak of ZIKV in...

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Bibliographic Details
Main Authors: Ali Munawar, Steven Beelen, Ahmad Munawar, Eveline Lescrinier, Sergei V. Strelkov
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
Zika virus
flaviviruses
NS3 helicase
antivirals
structure-based drug design
X-ray crystallography
fragment screening
drug discovery
protein–protein interaction inhibitor
allosteric inhibitor
Online Access:https://www.mdpi.com/1422-0067/19/11/3664

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https://www.mdpi.com/1422-0067/19/11/3664

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