Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome
Abstract Background The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome (pSS). Methods A total of 82 dry eye disease (DED) p...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-021-01871-0 |
| _version_ | 1818619434141483008 |
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| author | Ji Eun Kim Na Rae Kim Hee Seung Chin Kyoung Yul Seo Tae-im Kim Ji Won Jung |
| author_facet | Ji Eun Kim Na Rae Kim Hee Seung Chin Kyoung Yul Seo Tae-im Kim Ji Won Jung |
| author_sort | Ji Eun Kim |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome (pSS). Methods A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5 M were performed, and the Ocular Surface Disease Index was determined. Results In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 and β = 0.003, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049). Conclusions Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function. |
| first_indexed | 2024-12-16T17:37:25Z |
| format | Article |
| id | doaj.art-bdf43c938abc4f7d927d9a1999cd99ea |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-16T17:37:25Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-bdf43c938abc4f7d927d9a1999cd99ea2022-12-21T22:22:42ZengBMCBMC Ophthalmology1471-24152021-03-012111810.1186/s12886-021-01871-0Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndromeJi Eun Kim0Na Rae Kim1Hee Seung Chin2Kyoung Yul Seo3Tae-im Kim4Ji Won Jung5Department of Ophthalmology and Inha Vision Science Laboratory, Inha University School of MedicineDepartment of Ophthalmology and Inha Vision Science Laboratory, Inha University School of MedicineDepartment of Ophthalmology and Inha Vision Science Laboratory, Inha University School of MedicineDepartment of Ophthalmology, Severance Hospital, Yonsei University College of MedicineDepartment of Ophthalmology, Severance Hospital, Yonsei University College of MedicineDepartment of Ophthalmology and Inha Vision Science Laboratory, Inha University School of MedicineAbstract Background The aim of this study was to evaluate the effects of systemic parameters, laboratory findings, oral parameters, and other ocular surface parameters on ocular surface epithelial damage in patients with primary Sjögren’s syndrome (pSS). Methods A total of 82 dry eye disease (DED) patients with pSS were enrolled in this study. Ocular surface epithelial damage was measured by ocular staining score (OSS). Systemic parameters, laboratory findings including serologic markers, oral parameters, and other ocular surface parameters were collected. Other ocular surface parameter assessments such as the Schirmer’s test, fluorescein tear breakup time, meibomian gland examinations, noninvasive keratographic tear film break-up time measurements using the Keratograph® 5 M were performed, and the Ocular Surface Disease Index was determined. Results In a multivariate analysis, decreased age and increased duration of pSS were significantly related to increased logarithm-transformed OSS (β = -0.011, P = 0.043 and β = 0.003, P = 0.008). Among the ocular surface parameters, decreased fluorescein tear breakup time and increased MGD grade were significantly associated with increased logarithm-transformed OSS (β = -0.183, P < 0.001 and β = 0.192, P = 0.049). Conclusions Ocular surface epithelial damage in patients with pSS was associated with young age, long duration of disease, unstable tear film, and decreased meibomian gland function.https://doi.org/10.1186/s12886-021-01871-0Dry eye diseasePrimary Sjögren's syndromeOcular surface epithelial damageOcular staining scoreFluorescein tear break up timeMeibomian gland dysfunction |
| spellingShingle | Ji Eun Kim Na Rae Kim Hee Seung Chin Kyoung Yul Seo Tae-im Kim Ji Won Jung Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome BMC Ophthalmology Dry eye disease Primary Sjögren's syndrome Ocular surface epithelial damage Ocular staining score Fluorescein tear break up time Meibomian gland dysfunction |
| title | Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome |
| title_full | Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome |
| title_fullStr | Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome |
| title_full_unstemmed | Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome |
| title_short | Factors associated with ocular surface epithelial damage in patients with primary Sjögren’s syndrome |
| title_sort | factors associated with ocular surface epithelial damage in patients with primary sjogren s syndrome |
| topic | Dry eye disease Primary Sjögren's syndrome Ocular surface epithelial damage Ocular staining score Fluorescein tear break up time Meibomian gland dysfunction |
| url | https://doi.org/10.1186/s12886-021-01871-0 |
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