Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice

Abstract The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzheimer’s disease (AD) post-mortem brain tissue and in...

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Bibliographic Details
Main Authors:	Felipe C. Ribeiro, Danielle Cozachenco, Luana Heimfarth, Juliana T. S. Fortuna, Guilherme B. de Freitas, Jorge M. de Sousa, Soniza V. Alves-Leon, Renata E. P. Leite, Claudia K. Suemoto, Lea T. Grinberg, Fernanda G. De Felice, Mychael V. Lourenco, Sergio T. Ferreira
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-11-01
Series:	Communications Biology
Online Access:	https://doi.org/10.1038/s42003-023-05511-9

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