Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies

Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies

Hepatitis C virus (HCV) envelope glycoprotein heterodimer, E1E2, plays an essential role in virus entry and assembly. Furthermore, due to their exposure at the surface of the virion, these proteins are the major targets of anti-HCV neutralizing antibodies. Their ectodomain are heavily glycosylated w...

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Bibliographic Details
Main Authors:	Muriel Lavie, Xavier Hanoulle, Jean Dubuisson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-04-01
Series:	Frontiers in Immunology
Subjects:	hepatitis C virus neutralizing antibodies glycosylation humoral immune response glycoproteins
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00910/full

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