Diagnostic Challenges on the Laboratory Detection of Lupus Anticoagulant
Lupus anticoagulant (LA) is one of the three laboratory parameters (the others being antibodies to either cardiolipin or β2-glycoprotein I) which defines the rare but potentially devastating condition known as antiphospholipid syndrome (APS). Testing for LA is a challenging task for the clinical lab...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/7/844 |
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| author | Armando Tripodi |
| author_facet | Armando Tripodi |
| author_sort | Armando Tripodi |
| collection | DOAJ |
| description | Lupus anticoagulant (LA) is one of the three laboratory parameters (the others being antibodies to either cardiolipin or β2-glycoprotein I) which defines the rare but potentially devastating condition known as antiphospholipid syndrome (APS). Testing for LA is a challenging task for the clinical laboratory because specific tests for its detection are not available. However, proper LA detection is paramount for patients’ management, as its persistent positivity in the presence of (previous or current) thrombotic events, candidate for long term anticoagulation. Guidelines for LA detection have been established and updated over the last two decades. Implementation of these guidelines across laboratories and participation to external quality assessment schemes are required to help standardize the diagnostic procedures and help clinicians for appropriate management of APS. This article aims to review the current state of the art and the challenges that clinical laboratories incur in the detection of LA. |
| first_indexed | 2024-03-10T09:45:21Z |
| format | Article |
| id | doaj.art-bdf8b4fda10146c1ada946b4771b98b7 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T09:45:21Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj.art-bdf8b4fda10146c1ada946b4771b98b72023-11-22T03:17:57ZengMDPI AGBiomedicines2227-90592021-07-019784410.3390/biomedicines9070844Diagnostic Challenges on the Laboratory Detection of Lupus AnticoagulantArmando Tripodi0IRCCS Ca’ Granda Ospedale Maggiore Foundation, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Via Pace 9, 20122 Milano, ItalyLupus anticoagulant (LA) is one of the three laboratory parameters (the others being antibodies to either cardiolipin or β2-glycoprotein I) which defines the rare but potentially devastating condition known as antiphospholipid syndrome (APS). Testing for LA is a challenging task for the clinical laboratory because specific tests for its detection are not available. However, proper LA detection is paramount for patients’ management, as its persistent positivity in the presence of (previous or current) thrombotic events, candidate for long term anticoagulation. Guidelines for LA detection have been established and updated over the last two decades. Implementation of these guidelines across laboratories and participation to external quality assessment schemes are required to help standardize the diagnostic procedures and help clinicians for appropriate management of APS. This article aims to review the current state of the art and the challenges that clinical laboratories incur in the detection of LA.https://www.mdpi.com/2227-9059/9/7/844antiphospholipid antibody syndromethrombosisanticoagulationactivated partial thromboplastin timedilute Russell viper venom test |
| spellingShingle | Armando Tripodi Diagnostic Challenges on the Laboratory Detection of Lupus Anticoagulant Biomedicines antiphospholipid antibody syndrome thrombosis anticoagulation activated partial thromboplastin time dilute Russell viper venom test |
| title | Diagnostic Challenges on the Laboratory Detection of Lupus Anticoagulant |
| title_full | Diagnostic Challenges on the Laboratory Detection of Lupus Anticoagulant |
| title_fullStr | Diagnostic Challenges on the Laboratory Detection of Lupus Anticoagulant |
| title_full_unstemmed | Diagnostic Challenges on the Laboratory Detection of Lupus Anticoagulant |
| title_short | Diagnostic Challenges on the Laboratory Detection of Lupus Anticoagulant |
| title_sort | diagnostic challenges on the laboratory detection of lupus anticoagulant |
| topic | antiphospholipid antibody syndrome thrombosis anticoagulation activated partial thromboplastin time dilute Russell viper venom test |
| url | https://www.mdpi.com/2227-9059/9/7/844 |
| work_keys_str_mv | AT armandotripodi diagnosticchallengesonthelaboratorydetectionoflupusanticoagulant |