How to Build Live-Cell Sensor Microdevices
There is a lot of discussion on how viruses (such as influenza and SARS-CoV-2) are transmitted in air, potentially from aerosols and respiratory droplets, and thus it is important to monitor the environment for the presence of an active pathogen. Currently, the presence of viruses is being determine...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/23/8/3886 |
| _version_ | 1797603524825055232 |
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| author | Pelagia-Irene Gouma |
| author_facet | Pelagia-Irene Gouma |
| author_sort | Pelagia-Irene Gouma |
| collection | DOAJ |
| description | There is a lot of discussion on how viruses (such as influenza and SARS-CoV-2) are transmitted in air, potentially from aerosols and respiratory droplets, and thus it is important to monitor the environment for the presence of an active pathogen. Currently, the presence of viruses is being determined using primarily nucleic acid-based detection methods, such as reverse transcription- polymerase chain reaction (RT-PCR) tests. Antigen tests have also been developed for this purpose. However, most nucleic acid and antigen methods fail to discriminate between a viable and a non-viable virus. Therefore, we present an alternative, innovative, and disruptive approach involving a live-cell sensor microdevice that captures the viruses (and bacteria) from the air, becomes infected by them, and emits signals for an early warning of the presence of pathogens. This perspective outlines the processes and components required for living sensors to monitor the presence of pathogens in built environments and highlights the opportunity to use immune sentinels in the cells of normal human skin to produce monitors for indoor air pollutants. |
| first_indexed | 2024-03-11T04:33:21Z |
| format | Article |
| id | doaj.art-bdfaf466ad9348fb954ce15d1022395a |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-11T04:33:21Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-bdfaf466ad9348fb954ce15d1022395a2023-11-17T21:16:01ZengMDPI AGSensors1424-82202023-04-01238388610.3390/s23083886How to Build Live-Cell Sensor MicrodevicesPelagia-Irene Gouma0Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USAThere is a lot of discussion on how viruses (such as influenza and SARS-CoV-2) are transmitted in air, potentially from aerosols and respiratory droplets, and thus it is important to monitor the environment for the presence of an active pathogen. Currently, the presence of viruses is being determined using primarily nucleic acid-based detection methods, such as reverse transcription- polymerase chain reaction (RT-PCR) tests. Antigen tests have also been developed for this purpose. However, most nucleic acid and antigen methods fail to discriminate between a viable and a non-viable virus. Therefore, we present an alternative, innovative, and disruptive approach involving a live-cell sensor microdevice that captures the viruses (and bacteria) from the air, becomes infected by them, and emits signals for an early warning of the presence of pathogens. This perspective outlines the processes and components required for living sensors to monitor the presence of pathogens in built environments and highlights the opportunity to use immune sentinels in the cells of normal human skin to produce monitors for indoor air pollutants.https://www.mdpi.com/1424-8220/23/8/3886live cell sensorscaffoldvolatolomicspathogen detectionenvironmental monitoring |
| spellingShingle | Pelagia-Irene Gouma How to Build Live-Cell Sensor Microdevices Sensors live cell sensor scaffold volatolomics pathogen detection environmental monitoring |
| title | How to Build Live-Cell Sensor Microdevices |
| title_full | How to Build Live-Cell Sensor Microdevices |
| title_fullStr | How to Build Live-Cell Sensor Microdevices |
| title_full_unstemmed | How to Build Live-Cell Sensor Microdevices |
| title_short | How to Build Live-Cell Sensor Microdevices |
| title_sort | how to build live cell sensor microdevices |
| topic | live cell sensor scaffold volatolomics pathogen detection environmental monitoring |
| url | https://www.mdpi.com/1424-8220/23/8/3886 |
| work_keys_str_mv | AT pelagiairenegouma howtobuildlivecellsensormicrodevices |