Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride lipase (ATGL, Pnpla2 gene). BMAd-Pnpla2-/- mice have impaired BMAd lipolysis, and increased size and number of BMAds at baselin...

Full description

Bibliographic Details
Main Authors: Ziru Li, Emily Bowers, Junxiong Zhu, Hui Yu, Julie Hardij, Devika P Bagchi, Hiroyuki Mori, Kenneth T Lewis, Katrina Granger, Rebecca L Schill, Steven M Romanelli, Simin Abrishami, Kurt D Hankenson, Kanakadurga Singer, Clifford J Rosen, Ormond A MacDougald
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
bone marrow adipocyte
lipolysis
adipose triglyceride lipase
caloric restriction
bone
hematopoiesis
Online Access:https://elifesciences.org/articles/78496

Internet

https://elifesciences.org/articles/78496

Similar Items