Inhibition of TLR4/MAPKs Pathway Contributes to the Protection of Salvianolic Acid A Against Lipotoxicity-Induced Myocardial Damage in Cardiomyocytes and Obese Mice

Inhibition of TLR4/MAPKs Pathway Contributes to the Protection of Salvianolic Acid A Against Lipotoxicity-Induced Myocardial Damage in Cardiomyocytes and Obese Mice

The occurrence of lipotoxicity during obesity-associated cardiomyopathy is detrimental to health. Salvianolic acid A (SAA), a natural polyphenol extract of Salvia miltiorrhiza Bunge (Danshen in China), is known to be cardioprotective. However, its clinical benefits against obesity-associated cardiom...

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Bibliographic Details
Main Authors: Zhen Yang, Yanli Chen, Zhaoyuan Yan, Tian Tian Xu, Xiangyao Wu, Aiwen Pi, Qingsheng Liu, Hui Chai, Songtao Li, Xiaobing Dou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
salvianolic acid A
lipotoxicity
myocardial injury
TLR4
MAPKs
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.627123/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.627123/full

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