L-Lysine α-Oxidase: Enzyme with Anticancer Properties
L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H<sub>2</sub>O<sub>2</sub>, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO...
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MDPI AG
2021-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/11/1070 |
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| author | Elena V. Lukasheva Gulalek Babayeva Saida Sh. Karshieva Dmitry D. Zhdanov Vadim S. Pokrovsky |
| author_facet | Elena V. Lukasheva Gulalek Babayeva Saida Sh. Karshieva Dmitry D. Zhdanov Vadim S. Pokrovsky |
| author_sort | Elena V. Lukasheva |
| collection | DOAJ |
| description | L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H<sub>2</sub>O<sub>2</sub>, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO. Unlike asparaginase, LO has a dual mechanism of action: depletion of L-lysine and formation of H<sub>2</sub>O<sub>2</sub>, both targeting tumor growth. Prominent results were obtained on murine and human tumor models, including human colon cancer xenografts HCT 116, LS174T, and T47D with maximum T/C 12, 37, and 36%, respectively. The data obtained from human cancer xenografts in immunodeficient mice confirm the potential of LO as an agent for colon cancer treatment. In this review, we discuss recently discovered molecular mechanisms of biological action and the potential of LO as anticancer enzyme. |
| first_indexed | 2024-03-10T05:10:18Z |
| format | Article |
| id | doaj.art-bdfdb068d6764ddab93558ebef56e2ac |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T05:10:18Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-bdfdb068d6764ddab93558ebef56e2ac2023-11-23T00:54:47ZengMDPI AGPharmaceuticals1424-82472021-10-011411107010.3390/ph14111070L-Lysine α-Oxidase: Enzyme with Anticancer PropertiesElena V. Lukasheva0Gulalek Babayeva1Saida Sh. Karshieva2Dmitry D. Zhdanov3Vadim S. Pokrovsky4Department of Biochemistry, Peoples’ Friendship University of Russia (RUDN University), Miklukho—Maklaya Street 6, 117198 Moscow, RussiaDepartment of Biochemistry, Peoples’ Friendship University of Russia (RUDN University), Miklukho—Maklaya Street 6, 117198 Moscow, RussiaLaboratory of Combined Treatment, N.N. Blokhin Cancer Research Center, Kashirskoe Shosse 24, 115478 Moscow, RussiaInstitute of Biomedical Chemistry, Pogodinskaya Street 10/8, 119121 Moscow, RussiaDepartment of Biochemistry, Peoples’ Friendship University of Russia (RUDN University), Miklukho—Maklaya Street 6, 117198 Moscow, RussiaL-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H<sub>2</sub>O<sub>2</sub>, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO. Unlike asparaginase, LO has a dual mechanism of action: depletion of L-lysine and formation of H<sub>2</sub>O<sub>2</sub>, both targeting tumor growth. Prominent results were obtained on murine and human tumor models, including human colon cancer xenografts HCT 116, LS174T, and T47D with maximum T/C 12, 37, and 36%, respectively. The data obtained from human cancer xenografts in immunodeficient mice confirm the potential of LO as an agent for colon cancer treatment. In this review, we discuss recently discovered molecular mechanisms of biological action and the potential of LO as anticancer enzyme.https://www.mdpi.com/1424-8247/14/11/1070anticancer enzymestumor therapyL-amino acid oxidaseL-lysine α-oxidaseL-lysinecolon cancer treatment |
| spellingShingle | Elena V. Lukasheva Gulalek Babayeva Saida Sh. Karshieva Dmitry D. Zhdanov Vadim S. Pokrovsky L-Lysine α-Oxidase: Enzyme with Anticancer Properties Pharmaceuticals anticancer enzymes tumor therapy L-amino acid oxidase L-lysine α-oxidase L-lysine colon cancer treatment |
| title | L-Lysine α-Oxidase: Enzyme with Anticancer Properties |
| title_full | L-Lysine α-Oxidase: Enzyme with Anticancer Properties |
| title_fullStr | L-Lysine α-Oxidase: Enzyme with Anticancer Properties |
| title_full_unstemmed | L-Lysine α-Oxidase: Enzyme with Anticancer Properties |
| title_short | L-Lysine α-Oxidase: Enzyme with Anticancer Properties |
| title_sort | l lysine α oxidase enzyme with anticancer properties |
| topic | anticancer enzymes tumor therapy L-amino acid oxidase L-lysine α-oxidase L-lysine colon cancer treatment |
| url | https://www.mdpi.com/1424-8247/14/11/1070 |
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