One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery
The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the...
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MDPI AG
2019-02-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/12/3/540 |
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| author | Črt Dragar Tanja Potrč Sebastjan Nemec Robert Roškar Stane Pajk Petra Kocbek Slavko Kralj |
| author_facet | Črt Dragar Tanja Potrč Sebastjan Nemec Robert Roškar Stane Pajk Petra Kocbek Slavko Kralj |
| author_sort | Črt Dragar |
| collection | DOAJ |
| description | The development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The method is based on hot homogenization of a hydrophobic phase containing a nonpolar surfactant into an aqueous phase, using ultrasonication. The solvent-free hydrophobic phase that contained tetradecan-1-ol, γ-Fe<sub>2</sub>O<sub>3</sub> nanocrystals, orlistat, and surfactant was dispersed into a warm aqueous surfactant solution, with the formation of small droplets. Then, a pre-cooled aqueous phase was added for rapid cooling and the formation of solid magnetic nanocarriers. Two different nonpolar surfactants, polyethylene glycol dodecyl ether (B4) and our own <i>N</i><sup>1</sup>,<i>N</i><sup>1</sup>-dimethyl-<i>N</i><sup>2</sup>-(tricosan-12-yl)ethane-1,2-diamine (SP11), were investigated for the preparation of MC-B4 and MC-SP11 magnetic nanocarriers, respectively. The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes <160 nm, good colloidal stability, and high drug loading (7.65 wt.%). The MC-B4 nanocarriers showed prolonged drug release, while no drug release was seen for the MC-SP11 nanocarriers over the same time frame. Thus, the selection of a nonpolar surfactant for preparation of magnetic nanocarriers is crucial to enable drug release from nanocarrier. |
| first_indexed | 2024-04-11T22:55:46Z |
| format | Article |
| id | doaj.art-bdfee15ca122408dae43d8b64b2e571e |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-04-11T22:55:46Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-bdfee15ca122408dae43d8b64b2e571e2022-12-22T03:58:25ZengMDPI AGMaterials1996-19442019-02-0112354010.3390/ma12030540ma12030540One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug DeliveryČrt Dragar0Tanja Potrč1Sebastjan Nemec2Robert Roškar3Stane Pajk4Petra Kocbek5Slavko Kralj6Department for Materials Synthesis, Jožef Stefan Institute, 1000 Ljubljana, SloveniaFaculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, SloveniaDepartment for Materials Synthesis, Jožef Stefan Institute, 1000 Ljubljana, SloveniaFaculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, SloveniaFaculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, SloveniaFaculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, SloveniaDepartment for Materials Synthesis, Jožef Stefan Institute, 1000 Ljubljana, SloveniaThe development of various magnetically-responsive nanostructures is of great importance in biomedicine. The controlled assembly of many small superparamagnetic nanocrystals into large multi-core clusters is needed for effective magnetic drug delivery. Here, we present a novel one-pot method for the preparation of multi-core clusters for drug delivery (i.e., magnetic nanocarriers). The method is based on hot homogenization of a hydrophobic phase containing a nonpolar surfactant into an aqueous phase, using ultrasonication. The solvent-free hydrophobic phase that contained tetradecan-1-ol, γ-Fe<sub>2</sub>O<sub>3</sub> nanocrystals, orlistat, and surfactant was dispersed into a warm aqueous surfactant solution, with the formation of small droplets. Then, a pre-cooled aqueous phase was added for rapid cooling and the formation of solid magnetic nanocarriers. Two different nonpolar surfactants, polyethylene glycol dodecyl ether (B4) and our own <i>N</i><sup>1</sup>,<i>N</i><sup>1</sup>-dimethyl-<i>N</i><sup>2</sup>-(tricosan-12-yl)ethane-1,2-diamine (SP11), were investigated for the preparation of MC-B4 and MC-SP11 magnetic nanocarriers, respectively. The nanocarriers formed were of spherical shape, with mean hydrodynamic sizes <160 nm, good colloidal stability, and high drug loading (7.65 wt.%). The MC-B4 nanocarriers showed prolonged drug release, while no drug release was seen for the MC-SP11 nanocarriers over the same time frame. Thus, the selection of a nonpolar surfactant for preparation of magnetic nanocarriers is crucial to enable drug release from nanocarrier.https://www.mdpi.com/1996-1944/12/3/540magnetic nanocrystalsmagnetic drug deliverynanocarriersmulti-core particlesmagnetic nanoparticlesdrug release |
| spellingShingle | Črt Dragar Tanja Potrč Sebastjan Nemec Robert Roškar Stane Pajk Petra Kocbek Slavko Kralj One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery Materials magnetic nanocrystals magnetic drug delivery nanocarriers multi-core particles magnetic nanoparticles drug release |
| title | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
| title_full | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
| title_fullStr | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
| title_full_unstemmed | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
| title_short | One-Pot Method for Preparation of Magnetic Multi-Core Nanocarriers for Drug Delivery |
| title_sort | one pot method for preparation of magnetic multi core nanocarriers for drug delivery |
| topic | magnetic nanocrystals magnetic drug delivery nanocarriers multi-core particles magnetic nanoparticles drug release |
| url | https://www.mdpi.com/1996-1944/12/3/540 |
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