Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits
The crude extracts from medicinal plants are increasingly important for bioactive activities. Several parts of Morinda citrifolia have been utilized in traditional medicine, such as diabetes, anticancer, and hypertension. Therefore, the purpose of this research was to investigate the biological ac...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2022-06-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://sjst.psu.ac.th/journal/44-3/19.pdf |
| _version_ | 1827969433281232896 |
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| author | Jintana Masoongnoen Sompong Sansenya Kongaphisith Tongpoolsomjit Jarupa Viyoch Kanokorn Wechakorn |
| author_facet | Jintana Masoongnoen Sompong Sansenya Kongaphisith Tongpoolsomjit Jarupa Viyoch Kanokorn Wechakorn |
| author_sort | Jintana Masoongnoen |
| collection | DOAJ |
| description | The crude extracts from medicinal plants are increasingly important for bioactive activities. Several parts of Morinda
citrifolia have been utilized in traditional medicine, such as diabetes, anticancer, and hypertension. Therefore, the purpose of this
research was to investigate the biological activities, e.g., antioxidant, antidiabetic, and tyrosinase inhibitory activity of the crude
extracts of Morinda citrifolia unripe fruits. The highest percent extraction was found in methanol. The purified methanoic
fraction displayed the highest total phenolic content and was a potent tyrosinase inhibitor. The fraction of ethyl acetate exhibited
the highest flavonoid content and DPPH free radical scavenging capacity. Furthermore, the ethyl acetate and methanol fractions
were investigated as potent -glucosidase and -amylase inhibitors. Additionally, the cytotoxicity test of the bioactive fractions
was explored in human keratinocyte cell lines. |
| first_indexed | 2024-04-09T18:37:48Z |
| format | Article |
| id | doaj.art-be00973adbfa4e3da1a98845dae7e269 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-09T18:37:48Z |
| publishDate | 2022-06-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-be00973adbfa4e3da1a98845dae7e2692023-04-11T07:43:10ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952022-06-0144373574310.14456/sjst-psu.2022.99Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruitsJintana Masoongnoen0Sompong Sansenya1Kongaphisith Tongpoolsomjit2Jarupa Viyoch3Kanokorn Wechakorn4Department of Chemistry, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Pathum Thani, 12110 ThailandDepartment of Chemistry, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Pathum Thani, 12110 ThailandDepartment of Industrial Chemistry, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok, Bang Sue, Bangkok, 10800 ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Mueang, Phitsanulok, 65000 ThailandDepartment of Chemistry, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Pathum Thani, 12110 ThailandThe crude extracts from medicinal plants are increasingly important for bioactive activities. Several parts of Morinda citrifolia have been utilized in traditional medicine, such as diabetes, anticancer, and hypertension. Therefore, the purpose of this research was to investigate the biological activities, e.g., antioxidant, antidiabetic, and tyrosinase inhibitory activity of the crude extracts of Morinda citrifolia unripe fruits. The highest percent extraction was found in methanol. The purified methanoic fraction displayed the highest total phenolic content and was a potent tyrosinase inhibitor. The fraction of ethyl acetate exhibited the highest flavonoid content and DPPH free radical scavenging capacity. Furthermore, the ethyl acetate and methanol fractions were investigated as potent -glucosidase and -amylase inhibitors. Additionally, the cytotoxicity test of the bioactive fractions was explored in human keratinocyte cell lines.https://sjst.psu.ac.th/journal/44-3/19.pdfmorinda citrifolia unripe fruit extracttyrosinase inhibitionglucosidase inhibitionamylase inhibitionfree radical scavenging |
| spellingShingle | Jintana Masoongnoen Sompong Sansenya Kongaphisith Tongpoolsomjit Jarupa Viyoch Kanokorn Wechakorn Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits Songklanakarin Journal of Science and Technology (SJST) morinda citrifolia unripe fruit extract tyrosinase inhibition glucosidase inhibition amylase inhibition free radical scavenging |
| title | Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits |
| title_full | Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits |
| title_fullStr | Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits |
| title_full_unstemmed | Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits |
| title_short | Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits |
| title_sort | antidiabetic tyrosinase inhibitory and free radical scavenging activities of the purified extracts from morinda citrifolia unripe fruits |
| topic | morinda citrifolia unripe fruit extract tyrosinase inhibition glucosidase inhibition amylase inhibition free radical scavenging |
| url | https://sjst.psu.ac.th/journal/44-3/19.pdf |
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