Vaccinia Virus Attenuation by Codon Deoptimization of the A24R Gene for Vaccine Development

Vaccinia Virus Attenuation by Codon Deoptimization of the A24R Gene for Vaccine Development

ABSTRACT Poxviruses have large DNA genomes, and they are able to infect multiple vertebrate and invertebrate animals, including humans. Despite the eradication of smallpox, poxvirus infections still remain a significant public health concern. Vaccinia virus (VV) is the prototypic member in the poxvi...

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Bibliographic Details
Main Authors: María M. Lorenzo, Aitor Nogales, Kevin Chiem, Rafael Blasco, Luis Martínez-Sobrido
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
vaccinia virus
codon bias
codon deoptimization
A24R gene
live-attenuated vaccines
GFP
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00272-22

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