High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals: A technological description of integrated fNIRS and niABP mapping system
Introduction: The process of cerebral vessels maintaining cerebral blood flow (CBF) fairly constant over a wide range of arterial blood pressure is referred to as cerebral autoregulation (CA). Cerebrovascular reactivity is the mechanism behind this process, which maintains CBF through constriction a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1124268/full |
| _version_ | 1797945491674103808 |
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| author | Amanjyot Singh Sainbhi Logan Froese Alwyn Gomez Alwyn Gomez Izzy Marquez Fiorella Amenta Carleen Batson Kevin Y. Stein Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler |
| author_facet | Amanjyot Singh Sainbhi Logan Froese Alwyn Gomez Alwyn Gomez Izzy Marquez Fiorella Amenta Carleen Batson Kevin Y. Stein Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler |
| author_sort | Amanjyot Singh Sainbhi |
| collection | DOAJ |
| description | Introduction: The process of cerebral vessels maintaining cerebral blood flow (CBF) fairly constant over a wide range of arterial blood pressure is referred to as cerebral autoregulation (CA). Cerebrovascular reactivity is the mechanism behind this process, which maintains CBF through constriction and dilation of cerebral vessels. Traditionally CA has been assessed statistically, limited by large, immobile, and costly neuroimaging platforms. However, with recent technology advancement, dynamic autoregulation assessment is able to provide more detailed information on the evolution of CA over long periods of time with continuous assessment. Yet, to date, such continuous assessments have been hampered by low temporal and spatial resolution systems, that are typically reliant on invasive point estimations of pulsatile CBF or cerebral blood volume using commercially available technology.Methods: Using a combination of multi-channel functional near-infrared spectroscopy and non-invasive arterial blood pressure devices, we were able to create a system that visualizes CA metrics by converting them to heat maps drawn on a template of human brain.Results: The custom Python heat map module works in “offline” mode to visually portray the CA index per channel with the use of colourmap. The module was tested on two different mapping grids, 8 channel and 24 channel, using data from two separate recordings and the Python heat map module was able read the CA indices file and represent the data visually at a preselected rate of 10 s.Conclusion: The generation of the heat maps are entirely non-invasive, with high temporal and spatial resolution by leveraging the recent advances in NIRS technology along with niABP. The CA mapping system is in its initial stage and development plans are ready to transform it from “offline” to real-time heat map generation. |
| first_indexed | 2024-04-10T20:55:57Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T20:55:57Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-be053256118d48b5b8700aa054f12d9a2023-01-23T06:13:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-01-011410.3389/fphys.2023.11242681124268High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals: A technological description of integrated fNIRS and niABP mapping systemAmanjyot Singh Sainbhi0Logan Froese1Alwyn Gomez2Alwyn Gomez3Izzy Marquez4Fiorella Amenta5Carleen Batson6Kevin Y. Stein7Frederick A. Zeiler8Frederick A. Zeiler9Frederick A. Zeiler10Frederick A. Zeiler11Frederick A. Zeiler12Biomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaBiomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaSection of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaUndergraduate Engineering Program, Department of Biosystems Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaUndergraduate Engineering Program, Department of Biosystems Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaBiomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaBiomedical Engineering, Price Faculty of Engineering, University of Manitoba, Winnipeg, MB, CanadaSection of Neurosurgery, Department of Surgery, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, CanadaDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenDivision of Anaesthesia, Department of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge, United KingdomIntroduction: The process of cerebral vessels maintaining cerebral blood flow (CBF) fairly constant over a wide range of arterial blood pressure is referred to as cerebral autoregulation (CA). Cerebrovascular reactivity is the mechanism behind this process, which maintains CBF through constriction and dilation of cerebral vessels. Traditionally CA has been assessed statistically, limited by large, immobile, and costly neuroimaging platforms. However, with recent technology advancement, dynamic autoregulation assessment is able to provide more detailed information on the evolution of CA over long periods of time with continuous assessment. Yet, to date, such continuous assessments have been hampered by low temporal and spatial resolution systems, that are typically reliant on invasive point estimations of pulsatile CBF or cerebral blood volume using commercially available technology.Methods: Using a combination of multi-channel functional near-infrared spectroscopy and non-invasive arterial blood pressure devices, we were able to create a system that visualizes CA metrics by converting them to heat maps drawn on a template of human brain.Results: The custom Python heat map module works in “offline” mode to visually portray the CA index per channel with the use of colourmap. The module was tested on two different mapping grids, 8 channel and 24 channel, using data from two separate recordings and the Python heat map module was able read the CA indices file and represent the data visually at a preselected rate of 10 s.Conclusion: The generation of the heat maps are entirely non-invasive, with high temporal and spatial resolution by leveraging the recent advances in NIRS technology along with niABP. The CA mapping system is in its initial stage and development plans are ready to transform it from “offline” to real-time heat map generation.https://www.frontiersin.org/articles/10.3389/fphys.2023.1124268/fullcerebrovascular reactivity mapping systemcerebral autoregulationnear-infrared spectroscopyneuroimaging systemcerebral heat mapshigh temporal resolution |
| spellingShingle | Amanjyot Singh Sainbhi Logan Froese Alwyn Gomez Alwyn Gomez Izzy Marquez Fiorella Amenta Carleen Batson Kevin Y. Stein Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler Frederick A. Zeiler High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals: A technological description of integrated fNIRS and niABP mapping system Frontiers in Physiology cerebrovascular reactivity mapping system cerebral autoregulation near-infrared spectroscopy neuroimaging system cerebral heat maps high temporal resolution |
| title | High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals: A technological description of integrated fNIRS and niABP mapping system |
| title_full | High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals: A technological description of integrated fNIRS and niABP mapping system |
| title_fullStr | High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals: A technological description of integrated fNIRS and niABP mapping system |
| title_full_unstemmed | High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals: A technological description of integrated fNIRS and niABP mapping system |
| title_short | High spatial and temporal resolution cerebrovascular reactivity for humans and large mammals: A technological description of integrated fNIRS and niABP mapping system |
| title_sort | high spatial and temporal resolution cerebrovascular reactivity for humans and large mammals a technological description of integrated fnirs and niabp mapping system |
| topic | cerebrovascular reactivity mapping system cerebral autoregulation near-infrared spectroscopy neuroimaging system cerebral heat maps high temporal resolution |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1124268/full |
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