Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortality
IntroductionObesity in patients undergoing hemodialysis is common. However, there is limited information on the relationship between obesity types defined by the combined body mass index (BMI) and waist circumference (WC) classification criteria and all-cause mortality in Chinese hemodialysis patien...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1287834/full |
| _version_ | 1827782821875286016 |
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| author | Zhihua Shi Yidan Guo Pengpeng Ye Yang Luo |
| author_facet | Zhihua Shi Yidan Guo Pengpeng Ye Yang Luo |
| author_sort | Zhihua Shi |
| collection | DOAJ |
| description | IntroductionObesity in patients undergoing hemodialysis is common. However, there is limited information on the relationship between obesity types defined by the combined body mass index (BMI) and waist circumference (WC) classification criteria and all-cause mortality in Chinese hemodialysis patients. Our objective was to determine the association between obesity types and all-cause mortality in hemodialysis patients.MethodsWe conducted a prospective cohort study including patients from 11 hemodialysis centers in Beijing. According to the World Health Organization’s standards, patients were classified into 2 categories with WC and 4 categories with BMI and then followed up for 1 year. Kaplan–Meier survival analysis was used to compare the difference in the cumulative survival rate in different BMI and WC groups. A multivariate Cox regression analysis was used to determine the association between different types of obesity and all-cause mortality.ResultsA total of 613 patients were enrolled, the mean age was 63.8 ± 7.1 years old, and 42.1% were women. Based on the baseline BMI, there were 303 (49.4%) patients with normal weight, 227 (37.0%) with overweight, 37(6.0%) with obesity, and 46 (7.5%) with underweight. Based on the baseline WC, 346 (56.4%) patients had abdominal obesity. During a median follow-up of 52 weeks, 69 deaths occurred. Kaplan–Meier plots demonstrated a significant association of BMI categories (log-rank χ2 = 18.574, p<0.001) and WC categories (log-rank χ2 = 5.698, p=0.017) with all-cause death. With normal BMI and non-abdominal obesity as a reference, multivariate Cox regression analysis results showed that obesity (HR 5.36, 95% CI, 2.09-13.76, p<0.001), underweight (HR, 5.29, 95% CI, 2.32-12.07, p<0.001), normal weight combined with abdominal obesity (HR 2.61, 95% CI, 1.20-5.66, p=0.016), and overweight combined with abdominal obesity (HR 1.79, 95% CI, 1.03-3.73, p=0.031, respectively) were significantly associated with higher risks of all-cause mortality.ConclusionOur study indicated that abdominal obesity is common and associated with all-cause mortality among Chinese hemodialysis patients. |
| first_indexed | 2024-03-11T15:38:27Z |
| format | Article |
| id | doaj.art-be070ae88a344a0282bd1cc996e78891 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T15:38:27Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-be070ae88a344a0282bd1cc996e788912023-10-26T13:54:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12878341287834Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortalityZhihua Shi0Yidan Guo1Pengpeng Ye2Yang Luo3Division of Nephrology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDivision of Nephrology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaDivision of Injury Prevention and Mental Health, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, ChinaDivision of Nephrology, Beijing Shijitan Hospital, Capital Medical University, Beijing, ChinaIntroductionObesity in patients undergoing hemodialysis is common. However, there is limited information on the relationship between obesity types defined by the combined body mass index (BMI) and waist circumference (WC) classification criteria and all-cause mortality in Chinese hemodialysis patients. Our objective was to determine the association between obesity types and all-cause mortality in hemodialysis patients.MethodsWe conducted a prospective cohort study including patients from 11 hemodialysis centers in Beijing. According to the World Health Organization’s standards, patients were classified into 2 categories with WC and 4 categories with BMI and then followed up for 1 year. Kaplan–Meier survival analysis was used to compare the difference in the cumulative survival rate in different BMI and WC groups. A multivariate Cox regression analysis was used to determine the association between different types of obesity and all-cause mortality.ResultsA total of 613 patients were enrolled, the mean age was 63.8 ± 7.1 years old, and 42.1% were women. Based on the baseline BMI, there were 303 (49.4%) patients with normal weight, 227 (37.0%) with overweight, 37(6.0%) with obesity, and 46 (7.5%) with underweight. Based on the baseline WC, 346 (56.4%) patients had abdominal obesity. During a median follow-up of 52 weeks, 69 deaths occurred. Kaplan–Meier plots demonstrated a significant association of BMI categories (log-rank χ2 = 18.574, p<0.001) and WC categories (log-rank χ2 = 5.698, p=0.017) with all-cause death. With normal BMI and non-abdominal obesity as a reference, multivariate Cox regression analysis results showed that obesity (HR 5.36, 95% CI, 2.09-13.76, p<0.001), underweight (HR, 5.29, 95% CI, 2.32-12.07, p<0.001), normal weight combined with abdominal obesity (HR 2.61, 95% CI, 1.20-5.66, p=0.016), and overweight combined with abdominal obesity (HR 1.79, 95% CI, 1.03-3.73, p=0.031, respectively) were significantly associated with higher risks of all-cause mortality.ConclusionOur study indicated that abdominal obesity is common and associated with all-cause mortality among Chinese hemodialysis patients.https://www.frontiersin.org/articles/10.3389/fendo.2023.1287834/fullabdominal obesity cohort studyhemodialysiswaist circumferencebody mass indexall-cause mortality |
| spellingShingle | Zhihua Shi Yidan Guo Pengpeng Ye Yang Luo Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortality Frontiers in Endocrinology abdominal obesity cohort study hemodialysis waist circumference body mass index all-cause mortality |
| title | Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortality |
| title_full | Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortality |
| title_fullStr | Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortality |
| title_full_unstemmed | Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortality |
| title_short | Abdominal obesity in Chinese patients undergoing hemodialysis and its association with all-cause mortality |
| title_sort | abdominal obesity in chinese patients undergoing hemodialysis and its association with all cause mortality |
| topic | abdominal obesity cohort study hemodialysis waist circumference body mass index all-cause mortality |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1287834/full |
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