Determination of individual coumarin in a dry extract of Melilotus officinalis L.
Introduction. Substances of plant origin exhibit a variety of pharmacological activity in combination with a relatively low toxicity and frequency of side effects. In this regard, a promising direction is the standardization of substances of plant origin in the development of new herbal medicinal pr...
| Автори: | , , , , |
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| Формат: | Стаття |
| Мова: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2021-12-01
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| Серія: | Разработка и регистрация лекарственных средств |
| Предмети: | |
| Онлайн доступ: | https://www.pharmjournal.ru/jour/article/view/1107 |
| _version_ | 1826569706033643520 |
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| author | M. V. Aroyan Yu. E. Generalova I. I. Terninko I. E. Kaukhova E. K. Novikova |
| author_facet | M. V. Aroyan Yu. E. Generalova I. I. Terninko I. E. Kaukhova E. K. Novikova |
| author_sort | M. V. Aroyan |
| collection | DOAJ |
| description | Introduction. Substances of plant origin exhibit a variety of pharmacological activity in combination with a relatively low toxicity and frequency of side effects. In this regard, a promising direction is the standardization of substances of plant origin in the development of new herbal medicinal products.Aim. Qualitative and quantitative determination of individual coumarin in a dry extract of Melilotus оfficinalis L.Materials and methods. A dry extract of the Melilotus officinalis L. was used as an object of research. Determination of individual coumarin was carried out by high-performance liquid chromatography.Results and discussion. As a result of the research, coumarin was identified by high performance liquid chromatography based on comparison of retention times of the sample with retention times of a standard sample of coumarin in the sample of dry extract under research. The coumarin contents in the dry extract was 0.642 ± 0.007 %.Conclusion. The data obtained on the qualitative and quantitative content of coumarin in the dry extract of Melilotus оfficinalis L. were used in the development of the draft version specification of quality indicators. |
| first_indexed | 2024-04-10T01:39:33Z |
| format | Article |
| id | doaj.art-be095eda73204b46a3ce3ecea2a79973 |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2025-03-14T11:43:35Z |
| publishDate | 2021-12-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-be095eda73204b46a3ce3ecea2a799732025-03-02T09:53:26ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492021-12-0110410410710.33380/2305-2066-2021-10-4(1)-104-107914Determination of individual coumarin in a dry extract of Melilotus officinalis L.M. V. Aroyan0Yu. E. Generalova1I. I. Terninko2I. E. Kaukhova3E. K. Novikova4Saint-Petersburg State Chemical-Pharmaceutical UniversitySaint-Petersburg State Chemical-Pharmaceutical UniversitySaint-Petersburg State Chemical-Pharmaceutical UniversitySaint-Petersburg State Chemical-Pharmaceutical UniversitySaint-Petersburg State Chemical-Pharmaceutical UniversityIntroduction. Substances of plant origin exhibit a variety of pharmacological activity in combination with a relatively low toxicity and frequency of side effects. In this regard, a promising direction is the standardization of substances of plant origin in the development of new herbal medicinal products.Aim. Qualitative and quantitative determination of individual coumarin in a dry extract of Melilotus оfficinalis L.Materials and methods. A dry extract of the Melilotus officinalis L. was used as an object of research. Determination of individual coumarin was carried out by high-performance liquid chromatography.Results and discussion. As a result of the research, coumarin was identified by high performance liquid chromatography based on comparison of retention times of the sample with retention times of a standard sample of coumarin in the sample of dry extract under research. The coumarin contents in the dry extract was 0.642 ± 0.007 %.Conclusion. The data obtained on the qualitative and quantitative content of coumarin in the dry extract of Melilotus оfficinalis L. were used in the development of the draft version specification of quality indicators.https://www.pharmjournal.ru/jour/article/view/1107melilotus оfficinalis l.dry extractcoumarinhigh performance liquid chromatographyqualitative analysisquantitative analysis |
| spellingShingle | M. V. Aroyan Yu. E. Generalova I. I. Terninko I. E. Kaukhova E. K. Novikova Determination of individual coumarin in a dry extract of Melilotus officinalis L. Разработка и регистрация лекарственных средств melilotus оfficinalis l. dry extract coumarin high performance liquid chromatography qualitative analysis quantitative analysis |
| title | Determination of individual coumarin in a dry extract of Melilotus officinalis L. |
| title_full | Determination of individual coumarin in a dry extract of Melilotus officinalis L. |
| title_fullStr | Determination of individual coumarin in a dry extract of Melilotus officinalis L. |
| title_full_unstemmed | Determination of individual coumarin in a dry extract of Melilotus officinalis L. |
| title_short | Determination of individual coumarin in a dry extract of Melilotus officinalis L. |
| title_sort | determination of individual coumarin in a dry extract of melilotus officinalis l |
| topic | melilotus оfficinalis l. dry extract coumarin high performance liquid chromatography qualitative analysis quantitative analysis |
| url | https://www.pharmjournal.ru/jour/article/view/1107 |
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