Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review
BackgroundNeuropsychiatric disturbances and chorea are less recognized consequences of polycythemia vera (PV), and their role in post-PV myelofibrosis (MF) has not been reported. Clinical features that predict post-PV MF lack specificity.Case presentationWe describe an elderly patient with PV who de...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1253468/full |
| _version_ | 1797677103363129344 |
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| author | Li Li Min Zhou Yun-Qin Wu Wei-Nv Fan Da Li |
| author_facet | Li Li Min Zhou Yun-Qin Wu Wei-Nv Fan Da Li |
| author_sort | Li Li |
| collection | DOAJ |
| description | BackgroundNeuropsychiatric disturbances and chorea are less recognized consequences of polycythemia vera (PV), and their role in post-PV myelofibrosis (MF) has not been reported. Clinical features that predict post-PV MF lack specificity.Case presentationWe describe an elderly patient with PV who developed acute-onset reversible neuropsychiatric disturbances accompanied by generalized chorea and was finally diagnosed with post-PV MF after a bone marrow examination. We also reviewed four cases of late PV associated with neuropsychiatric symptoms since 1966 and analyzed their clinical characteristics and therapeutic effects.ConclusionOur case indicates that Janus kinase 2 (JAK2)-related PV is a treatable cause of late-onset chorea and that chorea may herald the deterioration of hematological parameters. Our case provides a clinically specific representation of post-PV MF. Patients with a long course of PV are recommended to undergo bone marrow re-examinations when they present with neuropsychiatric symptoms to achieve an early diagnosis of post-PV MF. |
| first_indexed | 2024-03-11T22:40:10Z |
| format | Article |
| id | doaj.art-be09969f296045a185aeb9971f96e35a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T22:40:10Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-be09969f296045a185aeb9971f96e35a2023-09-22T09:19:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-09-011410.3389/fneur.2023.12534681253468Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature reviewLi LiMin ZhouYun-Qin WuWei-Nv FanDa LiBackgroundNeuropsychiatric disturbances and chorea are less recognized consequences of polycythemia vera (PV), and their role in post-PV myelofibrosis (MF) has not been reported. Clinical features that predict post-PV MF lack specificity.Case presentationWe describe an elderly patient with PV who developed acute-onset reversible neuropsychiatric disturbances accompanied by generalized chorea and was finally diagnosed with post-PV MF after a bone marrow examination. We also reviewed four cases of late PV associated with neuropsychiatric symptoms since 1966 and analyzed their clinical characteristics and therapeutic effects.ConclusionOur case indicates that Janus kinase 2 (JAK2)-related PV is a treatable cause of late-onset chorea and that chorea may herald the deterioration of hematological parameters. Our case provides a clinically specific representation of post-PV MF. Patients with a long course of PV are recommended to undergo bone marrow re-examinations when they present with neuropsychiatric symptoms to achieve an early diagnosis of post-PV MF.https://www.frontiersin.org/articles/10.3389/fneur.2023.1253468/fullpost-polycythemia vera myelofibrosis (post-PV MF)neuropsychiatric symptoms (NPS)choreamicrocirculation disorderJanus kinase 2 (JAK2) |
| spellingShingle | Li Li Min Zhou Yun-Qin Wu Wei-Nv Fan Da Li Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review Frontiers in Neurology post-polycythemia vera myelofibrosis (post-PV MF) neuropsychiatric symptoms (NPS) chorea microcirculation disorder Janus kinase 2 (JAK2) |
| title | Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review |
| title_full | Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review |
| title_fullStr | Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review |
| title_full_unstemmed | Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review |
| title_short | Neuropsychiatric disturbance detecting polycythemia vera myelofibrosis: a case report and literature review |
| title_sort | neuropsychiatric disturbance detecting polycythemia vera myelofibrosis a case report and literature review |
| topic | post-polycythemia vera myelofibrosis (post-PV MF) neuropsychiatric symptoms (NPS) chorea microcirculation disorder Janus kinase 2 (JAK2) |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1253468/full |
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