Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics

Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failur...

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Main Authors: Jayaseelan Murugaiyan, P. Anand Kumar, G. Srinivasa Rao, Katia Iskandar, Stephen Hawser, John P. Hays, Yara Mohsen, Saranya Adukkadukkam, Wireko Andrew Awuah, Ruiz Alvarez Maria Jose, Nanono Sylvia, Esther Patience Nansubuga, Bruno Tilocca, Paola Roncada, Natalia Roson-Calero, Javier Moreno-Morales, Rohul Amin, Ballamoole Krishna Kumar, Abishek Kumar, Abdul-Rahman Toufik, Thaint Nadi Zaw, Oluwatosin O. Akinwotu, Maneesh Paul Satyaseela, Maarten B. M. van Dongen
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antibiotics
Subjects:
Online Access:https://www.mdpi.com/2079-6382/11/2/200
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author Jayaseelan Murugaiyan
P. Anand Kumar
G. Srinivasa Rao
Katia Iskandar
Stephen Hawser
John P. Hays
Yara Mohsen
Saranya Adukkadukkam
Wireko Andrew Awuah
Ruiz Alvarez Maria Jose
Nanono Sylvia
Esther Patience Nansubuga
Bruno Tilocca
Paola Roncada
Natalia Roson-Calero
Javier Moreno-Morales
Rohul Amin
Ballamoole Krishna Kumar
Abishek Kumar
Abdul-Rahman Toufik
Thaint Nadi Zaw
Oluwatosin O. Akinwotu
Maneesh Paul Satyaseela
Maarten B. M. van Dongen
author_facet Jayaseelan Murugaiyan
P. Anand Kumar
G. Srinivasa Rao
Katia Iskandar
Stephen Hawser
John P. Hays
Yara Mohsen
Saranya Adukkadukkam
Wireko Andrew Awuah
Ruiz Alvarez Maria Jose
Nanono Sylvia
Esther Patience Nansubuga
Bruno Tilocca
Paola Roncada
Natalia Roson-Calero
Javier Moreno-Morales
Rohul Amin
Ballamoole Krishna Kumar
Abishek Kumar
Abdul-Rahman Toufik
Thaint Nadi Zaw
Oluwatosin O. Akinwotu
Maneesh Paul Satyaseela
Maarten B. M. van Dongen
author_sort Jayaseelan Murugaiyan
collection DOAJ
description Antibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure of conventional, traditional antimicrobial therapy, in the past two decades, no novel class of antibiotics has been introduced. Consequently, several novel alternative strategies to combat these (multi-) drug-resistant infectious microorganisms have been identified. The purpose of this review is to gather and consider the strategies that are being applied or proposed as potential alternatives to traditional antibiotics. These strategies include combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods, and unconventional techniques, including the CRISPR-Cas system. These alternative strategies may have the potential to change the treatment of multi-drug-resistant pathogens in human clinical settings.
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spelling doaj.art-be09cea7f3a04f3e86dcdff64f84592e2023-11-23T18:28:07ZengMDPI AGAntibiotics2079-63822022-02-0111220010.3390/antibiotics11020200Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on AntibioticsJayaseelan Murugaiyan0P. Anand Kumar1G. Srinivasa Rao2Katia Iskandar3Stephen Hawser4John P. Hays5Yara Mohsen6Saranya Adukkadukkam7Wireko Andrew Awuah8Ruiz Alvarez Maria Jose9Nanono Sylvia10Esther Patience Nansubuga11Bruno Tilocca12Paola Roncada13Natalia Roson-Calero14Javier Moreno-Morales15Rohul Amin16Ballamoole Krishna Kumar17Abishek Kumar18Abdul-Rahman Toufik19Thaint Nadi Zaw20Oluwatosin O. Akinwotu21Maneesh Paul Satyaseela22Maarten B. M. van Dongen23Department of Biological Sciences, SRM University-AP, Guntur District, Amaravati 522240, IndiaDepartment of Veterinary Microbiology, NTR College of Veterinary Science, Sri Venkateswara Veterinary University, Gannavaram 521102, IndiaDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Sri Venkateswara Veterinary University, Tirupati 517502, IndiaDepartment of Mathématiques Informatique et Télécommunications, Université Toulouse III, Paul Sabatier, INSERM, UMR 1295, 31000 Toulouse, FranceIHMA Europe Sàrl, 1870 Monthey, SwitzerlandDepartment of Medical Microbiology, Infectious Diseases, Erasmus University Medical Centre (Erasmus MC), 3015 GD Rotterdam, The NetherlandsDepartment of Epidemiology, High Institute of Public Health, Alexandria University, Alexandria 21544, EgyptDepartment of Biological Sciences, SRM University-AP, Guntur District, Amaravati 522240, IndiaFaculty of Medicine, Sumy State University, 40007 Sumy, UkraineResearch Coordination and Support Service, National Institute of Health (ISS) Viale Regina -Elena, 299, 00161 Rome, ItalyInfectious Diseases Institute (IDI), College of Health Sciences, Makerere University, Kampala 7072, UgandaSchool of Medicine, University of Leeds, Leeds LS2 9JT, UKDepartment of Health Science, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Science, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, ItalyISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, SpainISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, SpainJames P Grant School of Public Health, BRAC University, Dhaka 1212, BangladeshNitte (Deemed to be University), Division of Infectious Diseases, Nitte University Centre for Science Education and Research, Deralakatte, Mangalore 575018, IndiaDepartment of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, IndiaFaculty of Medicine, Sumy State University, 40007 Sumy, UkraineOxford University Hospitals NHS Foundation Trust, Oxford OX3 9DU, UKDepartment of Microbiology and Biotechnology Centre, Maharaja Sayajirao University of Baroda, Vadodara 390002, IndiaAcharya Institute of Technology, Soladevanahalli, Bengaluru 560107, IndiaAMR Insights, 1017 EG Amsterdam, The NetherlandsAntibiotic resistance, and, in a broader perspective, antimicrobial resistance (AMR), continues to evolve and spread beyond all boundaries. As a result, infectious diseases have become more challenging or even impossible to treat, leading to an increase in morbidity and mortality. Despite the failure of conventional, traditional antimicrobial therapy, in the past two decades, no novel class of antibiotics has been introduced. Consequently, several novel alternative strategies to combat these (multi-) drug-resistant infectious microorganisms have been identified. The purpose of this review is to gather and consider the strategies that are being applied or proposed as potential alternatives to traditional antibiotics. These strategies include combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods, and unconventional techniques, including the CRISPR-Cas system. These alternative strategies may have the potential to change the treatment of multi-drug-resistant pathogens in human clinical settings.https://www.mdpi.com/2079-6382/11/2/200antimicrobial resistanceantibiotic resistanceantibiotic alternativesenzyme inhibitorsantimicrobial peptidesbacteriophages
spellingShingle Jayaseelan Murugaiyan
P. Anand Kumar
G. Srinivasa Rao
Katia Iskandar
Stephen Hawser
John P. Hays
Yara Mohsen
Saranya Adukkadukkam
Wireko Andrew Awuah
Ruiz Alvarez Maria Jose
Nanono Sylvia
Esther Patience Nansubuga
Bruno Tilocca
Paola Roncada
Natalia Roson-Calero
Javier Moreno-Morales
Rohul Amin
Ballamoole Krishna Kumar
Abishek Kumar
Abdul-Rahman Toufik
Thaint Nadi Zaw
Oluwatosin O. Akinwotu
Maneesh Paul Satyaseela
Maarten B. M. van Dongen
Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
Antibiotics
antimicrobial resistance
antibiotic resistance
antibiotic alternatives
enzyme inhibitors
antimicrobial peptides
bacteriophages
title Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
title_full Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
title_fullStr Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
title_full_unstemmed Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
title_short Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
title_sort progress in alternative strategies to combat antimicrobial resistance focus on antibiotics
topic antimicrobial resistance
antibiotic resistance
antibiotic alternatives
enzyme inhibitors
antimicrobial peptides
bacteriophages
url https://www.mdpi.com/2079-6382/11/2/200
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