The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma
Cytokines play an important role in regulating the immune response. Although there is great interest in exploiting cytokines for cancer immunotherapy, their clinical potential is limited by their pleiotropic properties and instability. A variety of cancer cell-intrinsic and extrinsic characteristics...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/14/3739 |
| _version_ | 1797589919791579136 |
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| author | Moloud Sooreshjani Shashwat Tripathi Corey Dussold Hinda Najem John de Groot Rimas V. Lukas Amy B. Heimberger |
| author_facet | Moloud Sooreshjani Shashwat Tripathi Corey Dussold Hinda Najem John de Groot Rimas V. Lukas Amy B. Heimberger |
| author_sort | Moloud Sooreshjani |
| collection | DOAJ |
| description | Cytokines play an important role in regulating the immune response. Although there is great interest in exploiting cytokines for cancer immunotherapy, their clinical potential is limited by their pleiotropic properties and instability. A variety of cancer cell-intrinsic and extrinsic characteristics pose a barrier to effective treatments including cytokines. Recent studies using gene and cell therapy offer new opportunities for targeting cytokines or their receptors, demonstrating that they are actionable targets. Current efforts such as virotherapy, systemic cytokine therapy, and cellular and gene therapy have provided novel strategies that incorporate cytokines as potential therapeutic strategies for glioblastoma. Ongoing research on characterizing the tumor microenvironment will be informative for prioritization and combinatorial strategies of cytokines for future clinical trials. Unique therapeutic opportunities exist at the convergence of cytokines that play a dual role in tumorigenesis and immune modulation. Here, we discuss the underlying strategies in pre- and clinical trials aiming to enhance treatment outcomes in glioblastoma patients. |
| first_indexed | 2024-03-11T01:12:58Z |
| format | Article |
| id | doaj.art-be0a11fd90b748ce8fb6b1b716480c3c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:12:58Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-be0a11fd90b748ce8fb6b1b716480c3c2023-11-18T18:43:28ZengMDPI AGCancers2072-66942023-07-011514373910.3390/cancers15143739The Use of Targeted Cytokines as Cancer Therapeutics in GlioblastomaMoloud Sooreshjani0Shashwat Tripathi1Corey Dussold2Hinda Najem3John de Groot4Rimas V. Lukas5Amy B. Heimberger6Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Neurosurgery, University of California San Francisco, San Francisco, CA 94143, USADepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USADepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USACytokines play an important role in regulating the immune response. Although there is great interest in exploiting cytokines for cancer immunotherapy, their clinical potential is limited by their pleiotropic properties and instability. A variety of cancer cell-intrinsic and extrinsic characteristics pose a barrier to effective treatments including cytokines. Recent studies using gene and cell therapy offer new opportunities for targeting cytokines or their receptors, demonstrating that they are actionable targets. Current efforts such as virotherapy, systemic cytokine therapy, and cellular and gene therapy have provided novel strategies that incorporate cytokines as potential therapeutic strategies for glioblastoma. Ongoing research on characterizing the tumor microenvironment will be informative for prioritization and combinatorial strategies of cytokines for future clinical trials. Unique therapeutic opportunities exist at the convergence of cytokines that play a dual role in tumorigenesis and immune modulation. Here, we discuss the underlying strategies in pre- and clinical trials aiming to enhance treatment outcomes in glioblastoma patients.https://www.mdpi.com/2072-6694/15/14/3739gliomacytokinestumor microenvironment |
| spellingShingle | Moloud Sooreshjani Shashwat Tripathi Corey Dussold Hinda Najem John de Groot Rimas V. Lukas Amy B. Heimberger The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma Cancers glioma cytokines tumor microenvironment |
| title | The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma |
| title_full | The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma |
| title_fullStr | The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma |
| title_full_unstemmed | The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma |
| title_short | The Use of Targeted Cytokines as Cancer Therapeutics in Glioblastoma |
| title_sort | use of targeted cytokines as cancer therapeutics in glioblastoma |
| topic | glioma cytokines tumor microenvironment |
| url | https://www.mdpi.com/2072-6694/15/14/3739 |
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