TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease
Stimulation of naïve CD4 T cells with weak T cell receptor agonists even in the absence of T helper-skewing cytokines can result in IL-4 production which can drive a Th2 response. Evidence for the in vivo consequences of such a phenomenon can be found in a number of mouse models and, importantly, a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00719/full |
| _version_ | 1828364160573898752 |
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| author | Joshua D. Milner |
| author_facet | Joshua D. Milner |
| author_sort | Joshua D. Milner |
| collection | DOAJ |
| description | Stimulation of naïve CD4 T cells with weak T cell receptor agonists even in the absence of T helper-skewing cytokines can result in IL-4 production which can drive a Th2 response. Evidence for the in vivo consequences of such a phenomenon can be found in a number of mouse models and, importantly, a series of monogenic human diseases associated with significant atopy which are caused by mutations in the T cell receptor signaling cascade. Such diseases can help understand how Th2 responses evolve in humans, and potentially provide insight into therapeutic interventions. |
| first_indexed | 2024-04-14T05:12:00Z |
| format | Article |
| id | doaj.art-be0bba8502d64287a00aa0e5480b3967 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T05:12:00Z |
| publishDate | 2018-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-be0bba8502d64287a00aa0e5480b39672022-12-22T02:10:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-04-01910.3389/fimmu.2018.00719349604TCR Signaling Abnormalities in Human Th2-Associated Atopic DiseaseJoshua D. MilnerStimulation of naïve CD4 T cells with weak T cell receptor agonists even in the absence of T helper-skewing cytokines can result in IL-4 production which can drive a Th2 response. Evidence for the in vivo consequences of such a phenomenon can be found in a number of mouse models and, importantly, a series of monogenic human diseases associated with significant atopy which are caused by mutations in the T cell receptor signaling cascade. Such diseases can help understand how Th2 responses evolve in humans, and potentially provide insight into therapeutic interventions.http://journal.frontiersin.org/article/10.3389/fimmu.2018.00719/fullT-cell receptor repertoiresignaling pathwaysprimary immunodeficienciesatopic diseasemonogenic syndromes |
| spellingShingle | Joshua D. Milner TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease Frontiers in Immunology T-cell receptor repertoire signaling pathways primary immunodeficiencies atopic disease monogenic syndromes |
| title | TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease |
| title_full | TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease |
| title_fullStr | TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease |
| title_full_unstemmed | TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease |
| title_short | TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease |
| title_sort | tcr signaling abnormalities in human th2 associated atopic disease |
| topic | T-cell receptor repertoire signaling pathways primary immunodeficiencies atopic disease monogenic syndromes |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00719/full |
| work_keys_str_mv | AT joshuadmilner tcrsignalingabnormalitiesinhumanth2associatedatopicdisease |