Challenges in drug discovery and description targeting Leishmania spp.: enzymes, structural proteins, and transporters

Challenges in drug discovery and description targeting Leishmania spp.: enzymes, structural proteins, and transporters

Leishmaniasis is a complex tropical disease caused by the protozoan parasite Leishmania spp. Classical chemotherapy includes pentavalent antimonial; however, pentamidine, amphotericin B, and miltefosine have been used. Chemo-resistance remains a risk for successful treatment; thus, target identifica...

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Bibliographic Details
Main Authors: Alexis Mendoza-León, María Luisa Serrano G., Alicia Ponte-Sucre
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Tropical Diseases
Subjects:
leishmaniasis
target
drug
treatment
tubulin
modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fitd.2023.1241044/full

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