VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection
Background: To elucidate the possible role of human cytomegalovirus in pregnancy loss through induction of certain pro-inflammatory adhesion molecules. Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2012-06-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/603 |
| _version_ | 1798036527643623424 |
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| author | Asmaa B Al-Obaidi Manal Adnan Habib Shatha Al-Zuhairy |
| author_facet | Asmaa B Al-Obaidi Manal Adnan Habib Shatha Al-Zuhairy |
| author_sort | Asmaa B Al-Obaidi |
| collection | DOAJ |
| description |
Background: To elucidate the possible role of human cytomegalovirus in pregnancy loss through induction of certain pro-inflammatory adhesion molecules.
Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein and VCAM-1 molecule.
Results: Nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a
significantly higher expression of VCAM-1 in HCMV positive cases as compared with HCMV negative and the control groups (p = 0.05, 0.001 respectively).
Conclusion: HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the surface expression of pro-inflammatory adhesion molecules like VCAM-1.
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| first_indexed | 2024-04-11T21:14:07Z |
| format | Article |
| id | doaj.art-be0d756adfa642f79e891006e8583272 |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-04-11T21:14:07Z |
| publishDate | 2012-06-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-be0d756adfa642f79e891006e85832722022-12-22T04:02:53ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652012-06-0181VCAM-1 Expression in Endometerium with Human Cytomegalovirus InfectionAsmaa B Al-Obaidi0Manal Adnan Habib1Shatha Al-Zuhairy2Al-Nahrain College of Medicine/Baghdad/IraqBaghdad College of Medicine/Baghdad/IraqAl-Nahrain College of Medicine/Baghdad/Iraq Background: To elucidate the possible role of human cytomegalovirus in pregnancy loss through induction of certain pro-inflammatory adhesion molecules. Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein and VCAM-1 molecule. Results: Nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a significantly higher expression of VCAM-1 in HCMV positive cases as compared with HCMV negative and the control groups (p = 0.05, 0.001 respectively). Conclusion: HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the surface expression of pro-inflammatory adhesion molecules like VCAM-1. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/603human cytomegalovirus,VCAM-1,Abortion |
| spellingShingle | Asmaa B Al-Obaidi Manal Adnan Habib Shatha Al-Zuhairy VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection مجله كليه طب الكندي human cytomegalovirus, VCAM-1, Abortion |
| title | VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection |
| title_full | VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection |
| title_fullStr | VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection |
| title_full_unstemmed | VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection |
| title_short | VCAM-1 Expression in Endometerium with Human Cytomegalovirus Infection |
| title_sort | vcam 1 expression in endometerium with human cytomegalovirus infection |
| topic | human cytomegalovirus, VCAM-1, Abortion |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/603 |
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