A Hyperflexible Electrode Array for Long‐Term Recording and Decoding of Intraspinal Neuronal Activity
Abstract Neural interfaces for stable access to the spinal cord (SC) electrical activity can benefit patients with motor dysfunctions. Invasive high‐density electrodes can directly extract signals from SC neuronal populations that can be used for the facilitation, adjustment, and reconstruction of m...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-11-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202303377 |
| _version_ | 1797465050630324224 |
|---|---|
| author | Jie Fan Xiaocheng Li Peiyu Wang Fan Yang Bingzhen Zhao Jianing Yang Zhengtuo Zhao Xue Li |
| author_facet | Jie Fan Xiaocheng Li Peiyu Wang Fan Yang Bingzhen Zhao Jianing Yang Zhengtuo Zhao Xue Li |
| author_sort | Jie Fan |
| collection | DOAJ |
| description | Abstract Neural interfaces for stable access to the spinal cord (SC) electrical activity can benefit patients with motor dysfunctions. Invasive high‐density electrodes can directly extract signals from SC neuronal populations that can be used for the facilitation, adjustment, and reconstruction of motor actions. However, developing neural interfaces that can achieve high channel counts and long‐term intraspinal recording remains technically challenging. Here, a biocompatible SC hyperflexible electrode array (SHEA) with an ultrathin structure that minimizes mechanical mismatch between the interface and SC tissue and enables stable single‐unit recording for more than 2 months in mice is demonstrated. These results show that SHEA maintains stable impedance, signal‐to‐noise ratio, single‐unit yield, and spike amplitude after implantation into mouse SC. Gait analysis and histology show that SHEA implantation induces negligible behavioral effects and Inflammation. Additionally, multi‐unit signals recorded from the SC ventral horn can predict the mouse's movement trajectory with a high decoding coefficient of up to 0.95. Moreover, during step cycles, it is found that the neural trajectory of spikes and low‐frequency local field potential (LFP) signal exhibits periodic geometry patterns. Thus, SHEA can offer an efficient and reliable SC neural interface for monitoring and potentially modulating SC neuronal activity associated with motor dysfunctions. |
| first_indexed | 2024-03-09T18:16:59Z |
| format | Article |
| id | doaj.art-be0dd3e0b9c74ee6ba0e4836ae91eff4 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-09T18:16:59Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-be0dd3e0b9c74ee6ba0e4836ae91eff42023-11-24T08:40:29ZengWileyAdvanced Science2198-38442023-11-011033n/an/a10.1002/advs.202303377A Hyperflexible Electrode Array for Long‐Term Recording and Decoding of Intraspinal Neuronal ActivityJie Fan0Xiaocheng Li1Peiyu Wang2Fan Yang3Bingzhen Zhao4Jianing Yang5Zhengtuo Zhao6Xue Li7Center for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 P. R. ChinaCenter for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 P. R. ChinaCenter for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 P. R. ChinaCenter for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 P. R. ChinaCenter for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 P. R. ChinaCenter for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 P. R. ChinaCenter for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 P. R. ChinaCenter for Excellence in Brain Science and Intelligence Technology Institute of Neuroscience Chinese Academy of Sciences Shanghai 200031 P. R. ChinaAbstract Neural interfaces for stable access to the spinal cord (SC) electrical activity can benefit patients with motor dysfunctions. Invasive high‐density electrodes can directly extract signals from SC neuronal populations that can be used for the facilitation, adjustment, and reconstruction of motor actions. However, developing neural interfaces that can achieve high channel counts and long‐term intraspinal recording remains technically challenging. Here, a biocompatible SC hyperflexible electrode array (SHEA) with an ultrathin structure that minimizes mechanical mismatch between the interface and SC tissue and enables stable single‐unit recording for more than 2 months in mice is demonstrated. These results show that SHEA maintains stable impedance, signal‐to‐noise ratio, single‐unit yield, and spike amplitude after implantation into mouse SC. Gait analysis and histology show that SHEA implantation induces negligible behavioral effects and Inflammation. Additionally, multi‐unit signals recorded from the SC ventral horn can predict the mouse's movement trajectory with a high decoding coefficient of up to 0.95. Moreover, during step cycles, it is found that the neural trajectory of spikes and low‐frequency local field potential (LFP) signal exhibits periodic geometry patterns. Thus, SHEA can offer an efficient and reliable SC neural interface for monitoring and potentially modulating SC neuronal activity associated with motor dysfunctions.https://doi.org/10.1002/advs.202303377hyperflexible electrodeintraspinal recordingneural decodingneural interfaceneural trajectory |
| spellingShingle | Jie Fan Xiaocheng Li Peiyu Wang Fan Yang Bingzhen Zhao Jianing Yang Zhengtuo Zhao Xue Li A Hyperflexible Electrode Array for Long‐Term Recording and Decoding of Intraspinal Neuronal Activity Advanced Science hyperflexible electrode intraspinal recording neural decoding neural interface neural trajectory |
| title | A Hyperflexible Electrode Array for Long‐Term Recording and Decoding of Intraspinal Neuronal Activity |
| title_full | A Hyperflexible Electrode Array for Long‐Term Recording and Decoding of Intraspinal Neuronal Activity |
| title_fullStr | A Hyperflexible Electrode Array for Long‐Term Recording and Decoding of Intraspinal Neuronal Activity |
| title_full_unstemmed | A Hyperflexible Electrode Array for Long‐Term Recording and Decoding of Intraspinal Neuronal Activity |
| title_short | A Hyperflexible Electrode Array for Long‐Term Recording and Decoding of Intraspinal Neuronal Activity |
| title_sort | hyperflexible electrode array for long term recording and decoding of intraspinal neuronal activity |
| topic | hyperflexible electrode intraspinal recording neural decoding neural interface neural trajectory |
| url | https://doi.org/10.1002/advs.202303377 |
| work_keys_str_mv | AT jiefan ahyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT xiaochengli ahyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT peiyuwang ahyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT fanyang ahyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT bingzhenzhao ahyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT jianingyang ahyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT zhengtuozhao ahyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT xueli ahyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT jiefan hyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT xiaochengli hyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT peiyuwang hyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT fanyang hyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT bingzhenzhao hyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT jianingyang hyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT zhengtuozhao hyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity AT xueli hyperflexibleelectrodearrayforlongtermrecordinganddecodingofintraspinalneuronalactivity |