Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome
Abstract Background Multivessel coronary disease (MVCD) is the common type of coronary artery disease in acute coronary syndrome (ACS). Coronary artery calcification (CAC) has been confirmed the strong predictor of major adverse cardiovascular events (MACEs). Several studies have validated that trig...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-022-01615-4 |
| _version_ | 1798000674371272704 |
|---|---|
| author | Jiayu Wang Xianwei Huang Caihua Fu Qiping Sheng Ping Liu |
| author_facet | Jiayu Wang Xianwei Huang Caihua Fu Qiping Sheng Ping Liu |
| author_sort | Jiayu Wang |
| collection | DOAJ |
| description | Abstract Background Multivessel coronary disease (MVCD) is the common type of coronary artery disease in acute coronary syndrome (ACS). Coronary artery calcification (CAC) has been confirmed the strong predictor of major adverse cardiovascular events (MACEs). Several studies have validated that triglyceride glucose (TyG) index can reflect the degree of coronary calcification or predict MACEs. However, no evidence to date has elucidated and compared the predictive intensity of TyG index or/and coronary artery calcification score (CACS) on multi-vascular disease and MACEs in ACS patients. Methods A total of 935 patients, diagnosed with ACS and experienced coronary computed tomography angiography (CCTA) from August 2015 to March 2022 in the Second Hospital of Shandong University, were selected for retrospective analysis. The subjects were divided into TyG index quartile 1–4 groups (Q1-Q4 groups), non-multivessel coronary disease (non-MVCD) and multivessel coronary disease (MVCD) groups, respectively. The general data, past medical or medication history, laboratory indicators, cardiac color Doppler ultrasound, CACS, and TyG indexes were respectively compared among these groups. The ROC curve preliminarily calculated and analyzed the diagnostic value of TyG index, CACS, and the combination of the two indicators for MVCD. Univariate and multivariate logistic regression analysis discriminated the independent hazard factors for forecasting MVCD. Results Compared with the lower TyG index and non-MVCD groups, the higher TyG index and MVCD groups had higher values of age, smoking history, waist circumference, systolic blood pressure, low-density lipoprotein cholesterol(LDL-C), fasting blood glucose and glycosylated hemoglobin, and CACS, but lower values of high-density lipoprotein cholesterol(HDL-C) (all P < 0.01). Coronary artery calcification is more common in the left anterior descending artery. Compared with non-MVCD, each unit increase in TyG index was associated with a 1.213-fold increased risk of MVCD. Logistic regression analysis adjusted for potential confounders indicated that TyG index is an independent risk factor for MVCD. With the increase of TyG index, the incidence of MACEs, apart from all-cause death, cardiac death, unexpected re-hospitalization of heart failure, recurrent ACS or unplanned revascularization, and non-fatal stroke in coronary artery increased (P log-rank < 0.001). Conclusion TyG index could completely substitute for CACS as a reliable, practical, and independent indicator for predicting the severity and prognosis of MVCD in patients with ACS. |
| first_indexed | 2024-04-11T11:24:07Z |
| format | Article |
| id | doaj.art-be0f6375edcb43689b636d462f7eb5e8 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-11T11:24:07Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-be0f6375edcb43689b636d462f7eb5e82022-12-22T04:26:21ZengBMCCardiovascular Diabetology1475-28402022-09-0121111810.1186/s12933-022-01615-4Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndromeJiayu Wang0Xianwei Huang1Caihua Fu2Qiping Sheng3Ping Liu4Department of Cardiology, The Second Hospital of Shandong University, Shandong UniversityDepartment of Cardiology, The Second Hospital of Shandong University, Shandong UniversityDepartment of Cardiology, Jinan Central Hospital Affiliated Shandong UniversityDepartment of Cardiology, The Second Hospital of Shandong University, Shandong UniversityDepartment of Cardiology, The Second Hospital of Shandong University, Shandong UniversityAbstract Background Multivessel coronary disease (MVCD) is the common type of coronary artery disease in acute coronary syndrome (ACS). Coronary artery calcification (CAC) has been confirmed the strong predictor of major adverse cardiovascular events (MACEs). Several studies have validated that triglyceride glucose (TyG) index can reflect the degree of coronary calcification or predict MACEs. However, no evidence to date has elucidated and compared the predictive intensity of TyG index or/and coronary artery calcification score (CACS) on multi-vascular disease and MACEs in ACS patients. Methods A total of 935 patients, diagnosed with ACS and experienced coronary computed tomography angiography (CCTA) from August 2015 to March 2022 in the Second Hospital of Shandong University, were selected for retrospective analysis. The subjects were divided into TyG index quartile 1–4 groups (Q1-Q4 groups), non-multivessel coronary disease (non-MVCD) and multivessel coronary disease (MVCD) groups, respectively. The general data, past medical or medication history, laboratory indicators, cardiac color Doppler ultrasound, CACS, and TyG indexes were respectively compared among these groups. The ROC curve preliminarily calculated and analyzed the diagnostic value of TyG index, CACS, and the combination of the two indicators for MVCD. Univariate and multivariate logistic regression analysis discriminated the independent hazard factors for forecasting MVCD. Results Compared with the lower TyG index and non-MVCD groups, the higher TyG index and MVCD groups had higher values of age, smoking history, waist circumference, systolic blood pressure, low-density lipoprotein cholesterol(LDL-C), fasting blood glucose and glycosylated hemoglobin, and CACS, but lower values of high-density lipoprotein cholesterol(HDL-C) (all P < 0.01). Coronary artery calcification is more common in the left anterior descending artery. Compared with non-MVCD, each unit increase in TyG index was associated with a 1.213-fold increased risk of MVCD. Logistic regression analysis adjusted for potential confounders indicated that TyG index is an independent risk factor for MVCD. With the increase of TyG index, the incidence of MACEs, apart from all-cause death, cardiac death, unexpected re-hospitalization of heart failure, recurrent ACS or unplanned revascularization, and non-fatal stroke in coronary artery increased (P log-rank < 0.001). Conclusion TyG index could completely substitute for CACS as a reliable, practical, and independent indicator for predicting the severity and prognosis of MVCD in patients with ACS.https://doi.org/10.1186/s12933-022-01615-4Triglyceride glucose product indexCoronary artery calcification scoreAcute coronary syndromeMultivessel diseaseCoronary computed tomography angiography |
| spellingShingle | Jiayu Wang Xianwei Huang Caihua Fu Qiping Sheng Ping Liu Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome Cardiovascular Diabetology Triglyceride glucose product index Coronary artery calcification score Acute coronary syndrome Multivessel disease Coronary computed tomography angiography |
| title | Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome |
| title_full | Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome |
| title_fullStr | Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome |
| title_full_unstemmed | Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome |
| title_short | Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome |
| title_sort | association between triglyceride glucose index coronary artery calcification and multivessel coronary disease in chinese patients with acute coronary syndrome |
| topic | Triglyceride glucose product index Coronary artery calcification score Acute coronary syndrome Multivessel disease Coronary computed tomography angiography |
| url | https://doi.org/10.1186/s12933-022-01615-4 |
| work_keys_str_mv | AT jiayuwang associationbetweentriglycerideglucoseindexcoronaryarterycalcificationandmultivesselcoronarydiseaseinchinesepatientswithacutecoronarysyndrome AT xianweihuang associationbetweentriglycerideglucoseindexcoronaryarterycalcificationandmultivesselcoronarydiseaseinchinesepatientswithacutecoronarysyndrome AT caihuafu associationbetweentriglycerideglucoseindexcoronaryarterycalcificationandmultivesselcoronarydiseaseinchinesepatientswithacutecoronarysyndrome AT qipingsheng associationbetweentriglycerideglucoseindexcoronaryarterycalcificationandmultivesselcoronarydiseaseinchinesepatientswithacutecoronarysyndrome AT pingliu associationbetweentriglycerideglucoseindexcoronaryarterycalcificationandmultivesselcoronarydiseaseinchinesepatientswithacutecoronarysyndrome |