Krüppel-like factors: Three fingers in control
<p>Abstract</p> <p>Krüppel-like factors (KLFs), members of the zinc-finger family of transcription factors capable of binding GC-rich sequences, have emerged as critical regulators of important functions all over the body. They are characterised by a highly conserved C-terminal DNA...
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| Format: | Article |
| Language: | English |
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BMC
2010-04-01
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| Series: | Human Genomics |
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| Online Access: | http://www.humgenomics.com/content/4/4/263 |
| _version_ | 1811184544193183744 |
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| author | Swamynathan Shivalingappa K |
| author_facet | Swamynathan Shivalingappa K |
| author_sort | Swamynathan Shivalingappa K |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Krüppel-like factors (KLFs), members of the zinc-finger family of transcription factors capable of binding GC-rich sequences, have emerged as critical regulators of important functions all over the body. They are characterised by a highly conserved C-terminal DNA-binding motif containing three C2H2 zinc-finger domains, with variable N-terminal regulatory domains. Currently, there are 17 KLFs annotated in the human genome. In spite of their structural similarity to one another, the genes encoding different KLFs are scattered all over the genome. By virtue of their ability to activate and/or repress the expression of a large number of genes, KLFs regulate a diverse array of developmental events and cellular processes, such as erythropoiesis, cardiac remodelling, adipogenesis, maintenance of stem cells, epithelial barrier formation, control of cell proliferation and neoplasia, flow-mediated endothelial gene expression, skeletal and smooth muscle development, gluconeogenesis, monocyte activation, intestinal and conjunctival goblet cell development, retinal neuronal regeneration and neonatal lung development. Characteristic features, nomenclature, evolution and functional diversities of the human KLFs are reviewed here.</p> |
| first_indexed | 2024-04-11T13:14:02Z |
| format | Article |
| id | doaj.art-be102e7e824b44dda2196819b3c8b5b8 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-11T13:14:02Z |
| publishDate | 2010-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-be102e7e824b44dda2196819b3c8b5b82022-12-22T04:22:27ZengBMCHuman Genomics1479-73642010-04-014426327010.1186/1479-7364-4-4-263Krüppel-like factors: Three fingers in controlSwamynathan Shivalingappa K<p>Abstract</p> <p>Krüppel-like factors (KLFs), members of the zinc-finger family of transcription factors capable of binding GC-rich sequences, have emerged as critical regulators of important functions all over the body. They are characterised by a highly conserved C-terminal DNA-binding motif containing three C2H2 zinc-finger domains, with variable N-terminal regulatory domains. Currently, there are 17 KLFs annotated in the human genome. In spite of their structural similarity to one another, the genes encoding different KLFs are scattered all over the genome. By virtue of their ability to activate and/or repress the expression of a large number of genes, KLFs regulate a diverse array of developmental events and cellular processes, such as erythropoiesis, cardiac remodelling, adipogenesis, maintenance of stem cells, epithelial barrier formation, control of cell proliferation and neoplasia, flow-mediated endothelial gene expression, skeletal and smooth muscle development, gluconeogenesis, monocyte activation, intestinal and conjunctival goblet cell development, retinal neuronal regeneration and neonatal lung development. Characteristic features, nomenclature, evolution and functional diversities of the human KLFs are reviewed here.</p>http://www.humgenomics.com/content/4/4/263gene expressionzinc-fingertranscription factorKrüppel-like factorDNA-binding |
| spellingShingle | Swamynathan Shivalingappa K Krüppel-like factors: Three fingers in control Human Genomics gene expression zinc-finger transcription factor Krüppel-like factor DNA-binding |
| title | Krüppel-like factors: Three fingers in control |
| title_full | Krüppel-like factors: Three fingers in control |
| title_fullStr | Krüppel-like factors: Three fingers in control |
| title_full_unstemmed | Krüppel-like factors: Three fingers in control |
| title_short | Krüppel-like factors: Three fingers in control |
| title_sort | kruppel like factors three fingers in control |
| topic | gene expression zinc-finger transcription factor Krüppel-like factor DNA-binding |
| url | http://www.humgenomics.com/content/4/4/263 |
| work_keys_str_mv | AT swamynathanshivalingappak kruppellikefactorsthreefingersincontrol |