Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee Osteoarthritis
The use of biologic therapies for the management of knee osteoarthritis (OA) has largely increased in recent years. The purpose of this study was to evaluate the efficiency and the therapeutic potential of platelet-rich plasma (PRP) and autologous adipose tissue (AAT) injections as a treatment for k...
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MDPI AG
2022-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/3/684 |
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| author | Jakub Kaszyński Paweł Bąkowski Bartosz Kiedrowski Łukasz Stołowski Anna Wasilewska-Burczyk Kamilla Grzywacz Tomasz Piontek |
| author_facet | Jakub Kaszyński Paweł Bąkowski Bartosz Kiedrowski Łukasz Stołowski Anna Wasilewska-Burczyk Kamilla Grzywacz Tomasz Piontek |
| author_sort | Jakub Kaszyński |
| collection | DOAJ |
| description | The use of biologic therapies for the management of knee osteoarthritis (OA) has largely increased in recent years. The purpose of this study was to evaluate the efficiency and the therapeutic potential of platelet-rich plasma (PRP) and autologous adipose tissue (AAT) injections as a treatment for knee OA. Sixty participants were enrolled in the study: 20 healthy ones and 40 with minimal to moderate knee OA (KL I-III). The OA patients were randomly assigned either to the PRP or to the AAT group. The PRP samples showed a low expression level of NF-κB-responsive gene CCL5 and high expression levels of classic inflammatory and TNF-l INF responses. The AAT injection product was prepared using a Lipogems device, and its regenerative potential as well as the ability for expansion of mesenchymal stem cells were tested in the cell culture conditions. The patient assessments were carried out five times. Significant improvement was observed regardless of the treatment method in the VAS, KOOS, WOMAC and IKDC 2000 subjective evaluations as well as in the functional parameters. Intra-articular injections of AAT or PRP improved pain, symptoms, quality of life and functional capacity with a comparable effectiveness in the patients with mild to moderate knee osteoarthritis. |
| first_indexed | 2024-03-09T13:49:26Z |
| format | Article |
| id | doaj.art-be105bf7bf2643718416067b8ba04d40 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:49:26Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-be105bf7bf2643718416067b8ba04d402023-11-30T20:53:26ZengMDPI AGBiomedicines2227-90592022-03-0110368410.3390/biomedicines10030684Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee OsteoarthritisJakub Kaszyński0Paweł Bąkowski1Bartosz Kiedrowski2Łukasz Stołowski3Anna Wasilewska-Burczyk4Kamilla Grzywacz5Tomasz Piontek6Department of Orthopedic Surgery, Rehasport Clinic, 60-201 Poznań, PolandDepartment of Orthopedic Surgery, Rehasport Clinic, 60-201 Poznań, PolandDepartment of Orthopedic Surgery, Rehasport Clinic, 60-201 Poznań, PolandDepartment of Orthopedic Surgery, Rehasport Clinic, 60-201 Poznań, PolandInstitute of Bioorganic Chemistry Polish Academy of Sciences, 61-704 Poznań, PolandInstitute of Bioorganic Chemistry Polish Academy of Sciences, 61-704 Poznań, PolandDepartment of Orthopedic Surgery, Rehasport Clinic, 60-201 Poznań, PolandThe use of biologic therapies for the management of knee osteoarthritis (OA) has largely increased in recent years. The purpose of this study was to evaluate the efficiency and the therapeutic potential of platelet-rich plasma (PRP) and autologous adipose tissue (AAT) injections as a treatment for knee OA. Sixty participants were enrolled in the study: 20 healthy ones and 40 with minimal to moderate knee OA (KL I-III). The OA patients were randomly assigned either to the PRP or to the AAT group. The PRP samples showed a low expression level of NF-κB-responsive gene CCL5 and high expression levels of classic inflammatory and TNF-l INF responses. The AAT injection product was prepared using a Lipogems device, and its regenerative potential as well as the ability for expansion of mesenchymal stem cells were tested in the cell culture conditions. The patient assessments were carried out five times. Significant improvement was observed regardless of the treatment method in the VAS, KOOS, WOMAC and IKDC 2000 subjective evaluations as well as in the functional parameters. Intra-articular injections of AAT or PRP improved pain, symptoms, quality of life and functional capacity with a comparable effectiveness in the patients with mild to moderate knee osteoarthritis.https://www.mdpi.com/2227-9059/10/3/684adipose-derived stem cellsautologous adipose tissueplatelet-rich plasmaknee osteoarthritis |
| spellingShingle | Jakub Kaszyński Paweł Bąkowski Bartosz Kiedrowski Łukasz Stołowski Anna Wasilewska-Burczyk Kamilla Grzywacz Tomasz Piontek Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee Osteoarthritis Biomedicines adipose-derived stem cells autologous adipose tissue platelet-rich plasma knee osteoarthritis |
| title | Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee Osteoarthritis |
| title_full | Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee Osteoarthritis |
| title_fullStr | Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee Osteoarthritis |
| title_full_unstemmed | Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee Osteoarthritis |
| title_short | Intra-Articular Injections of Autologous Adipose Tissue or Platelet-Rich Plasma Comparably Improve Clinical and Functional Outcomes in Patients with Knee Osteoarthritis |
| title_sort | intra articular injections of autologous adipose tissue or platelet rich plasma comparably improve clinical and functional outcomes in patients with knee osteoarthritis |
| topic | adipose-derived stem cells autologous adipose tissue platelet-rich plasma knee osteoarthritis |
| url | https://www.mdpi.com/2227-9059/10/3/684 |
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