Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization

Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in cellular deformation. Recently, Piezo1 channels...

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Bibliographic Details
Main Authors: Mayumi Matsunaga, Maki Kimura, Takehito Ouchi, Takashi Nakamura, Sadao Ohyama, Masayuki Ando, Sachie Nomura, Toshifumi Azuma, Tatsuya Ichinohe, Yoshiyuki Shibukawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
dentin
odontoblast
Piezo channel
mechanosensitive channel
tooth pain
orofacial pain
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.704518/full

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