Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2

Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2

Dexamethasone may reduce mortality in COVID-19 patients. Whether dexamethasone or endogenous glucocorticoids, such as cortisol, biochemically interact with SARS-CoV-2 spike 1 protein (S1), or its cellular receptor ACE2, is unknown. Using molecular dynamics (MD) simulations and binding energy calcula...

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Bibliographic Details
Main Authors: Hassan Sarker, Rashmi Panigrahi, Eugenio Hardy, J. N. Mark Glover, Shokrollah Elahi, Carlos Fernandez-Patron
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
glucocorticoids
SARS-CoV-2
ACE2 (angiotensin converting enzyme 2)
innate immunity
COVID
coronavirus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.906687/full

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