Crystal structure of vancomycin bound to the resistance determinant d-alanine-d-serine

Crystal structure of vancomycin bound to the resistance determinant d-alanine-d-serine

Vancomycin is a glycopeptide antibiotic that for decades has been a mainstay of treatment for persistent bacterial infections. However, the spread of antibiotic resistance threatens its continued utility. In particular, vancomycin-resistant enterococci (VRE) have become a pressing clinical challenge...

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Bibliographic Details
Main Authors: Jee Hoon Park, Rachel E. Reviello, Patrick J. Loll
Format: Article
Language:English
Published: International Union of Crystallography 2024-03-01
Series:IUCrJ
Subjects:
vancomycin
vancomycin-resistant enterococci
antibiotics
antibiotic resistance
supramolecular assembly
macromolecular machines
drug discovery
molecular recognition
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252524000289

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