The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production
Abstract The very low-density lipoprotein receptor (VLDLR) transports egg yolk precursors into oocytes. However, our knowledge of the distribution patterns of VLDLR variants among breeds and their relationship to egg production is still incomplete. In this study, eight single nucleotide polymorphism...
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Sociedade Brasileira de Genética
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300380&lng=en&tlng=en |
| _version_ | 1818941988983013376 |
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| author | ZhePeng Wang GuoHua Meng Na Li MingFen Yu XiaoWei Liang YuNa Min FuZhu Liu YuPeng Gao |
| author_facet | ZhePeng Wang GuoHua Meng Na Li MingFen Yu XiaoWei Liang YuNa Min FuZhu Liu YuPeng Gao |
| author_sort | ZhePeng Wang |
| collection | DOAJ |
| description | Abstract The very low-density lipoprotein receptor (VLDLR) transports egg yolk precursors into oocytes. However, our knowledge of the distribution patterns of VLDLR variants among breeds and their relationship to egg production is still incomplete. In this study, eight single nucleotide polymorphisms (SNPs) that account for 87% of all VLDLR variants were genotyped in Nick Chick (NC, n=91), Lohmann Brown (LohB, n=50) and Lueyang (LY, n=381) chickens, the latter being an Chinese indigenous breed. Egg production by NC and LY chickens was recorded from 17 to 50 weeks. Only four similar haplotypes were found in NC and LohB, of which two accounted for 100% of all NC haplotypes and 92.5% of LohB haplotypes. In contrast, there was considerable haplotypic diversity in LY. Comparison of egg production in LY showed that hens with NC-like haplotypes had a significantly higher production (p < 0.05) than those without the haplotypes. However, VLDLR expression was not significantly different between the haplotypes. These findings indicate a divergence in the distribution of VLDLR haplotypes between selected and non-selected breeds and suggest that the near fixation of VLDLR variants in NC and LohB is compatible with signature of selection. These data also support VLDLR as a candidate gene for modulating egg production. |
| first_indexed | 2024-12-20T07:04:17Z |
| format | Article |
| id | doaj.art-be114eb51f4d408aae77c329ce51aca9 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-20T07:04:17Z |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-be114eb51f4d408aae77c329ce51aca92022-12-21T19:49:07ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-468539338039110.1590/1678-4685-GMB-2015-0206S1415-47572016000300380The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg productionZhePeng WangGuoHua MengNa LiMingFen YuXiaoWei LiangYuNa MinFuZhu LiuYuPeng GaoAbstract The very low-density lipoprotein receptor (VLDLR) transports egg yolk precursors into oocytes. However, our knowledge of the distribution patterns of VLDLR variants among breeds and their relationship to egg production is still incomplete. In this study, eight single nucleotide polymorphisms (SNPs) that account for 87% of all VLDLR variants were genotyped in Nick Chick (NC, n=91), Lohmann Brown (LohB, n=50) and Lueyang (LY, n=381) chickens, the latter being an Chinese indigenous breed. Egg production by NC and LY chickens was recorded from 17 to 50 weeks. Only four similar haplotypes were found in NC and LohB, of which two accounted for 100% of all NC haplotypes and 92.5% of LohB haplotypes. In contrast, there was considerable haplotypic diversity in LY. Comparison of egg production in LY showed that hens with NC-like haplotypes had a significantly higher production (p < 0.05) than those without the haplotypes. However, VLDLR expression was not significantly different between the haplotypes. These findings indicate a divergence in the distribution of VLDLR haplotypes between selected and non-selected breeds and suggest that the near fixation of VLDLR variants in NC and LohB is compatible with signature of selection. These data also support VLDLR as a candidate gene for modulating egg production.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300380&lng=en&tlng=enchickenegg productionhaplotypevery low-density lipoprotein receptor (VLDLR) |
| spellingShingle | ZhePeng Wang GuoHua Meng Na Li MingFen Yu XiaoWei Liang YuNa Min FuZhu Liu YuPeng Gao The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production Genetics and Molecular Biology chicken egg production haplotype very low-density lipoprotein receptor (VLDLR) |
| title | The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production |
| title_full | The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production |
| title_fullStr | The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production |
| title_full_unstemmed | The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production |
| title_short | The association of very low-density lipoprotein receptor (VLDLR) haplotypes with egg production indicates VLDLR is a candidate gene for modulating egg production |
| title_sort | association of very low density lipoprotein receptor vldlr haplotypes with egg production indicates vldlr is a candidate gene for modulating egg production |
| topic | chicken egg production haplotype very low-density lipoprotein receptor (VLDLR) |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300380&lng=en&tlng=en |
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