Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection
Summary: Platelets have a great ability to modulate immune responses. Monocyte-platelet aggregates (MPAs) are associated with the pathogenesis of cardiac disease. Notably, a low preoperative platelet count often indicates poor postoperative recovery following acute aortic dissection (AAD). The funct...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223008829 |
| _version_ | 1797823726462435328 |
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| author | Wei-Yun Shen Hui Li An-Hui Zha Ru-Yi Luo Yan-Ling Zhang Cong Luo Ru-Ping Dai |
| author_facet | Wei-Yun Shen Hui Li An-Hui Zha Ru-Yi Luo Yan-Ling Zhang Cong Luo Ru-Ping Dai |
| author_sort | Wei-Yun Shen |
| collection | DOAJ |
| description | Summary: Platelets have a great ability to modulate immune responses. Monocyte-platelet aggregates (MPAs) are associated with the pathogenesis of cardiac disease. Notably, a low preoperative platelet count often indicates poor postoperative recovery following acute aortic dissection (AAD). The functions of platelets and MPAs in AAD, however, remain poorly understood. We found that, despite decreased platelet counts, platelets were also activated in AAD patients, with significant alterations in immune-modulating mediators. Of interest, monocytes in AAD patients had a suppressed immune status, which was correlated with poor outcomes following surgery. Interestingly, platelets preferentially aggregated with monocytes, and the levels of MPAs were related to recovery after surgical repair in AAD patients. Platelets restored suppressed monocyte functions in AAD patients by forming aggregates and partly by secreting matrix metalloproteinase-9 (MMP-9). Thus, the results point to a previously unknown mechanism for platelets involving monocyte reprogramming, which may improve postoperative outcomes following complex cardiovascular surgery. |
| first_indexed | 2024-03-13T10:28:15Z |
| format | Article |
| id | doaj.art-be136e49c3624e13aa9b18967da59c96 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-13T10:28:15Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-be136e49c3624e13aa9b18967da59c962023-05-19T04:46:19ZengElsevieriScience2589-00422023-06-01266106805Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissectionWei-Yun Shen0Hui Li1An-Hui Zha2Ru-Yi Luo3Yan-Ling Zhang4Cong Luo5Ru-Ping Dai6Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China; Anesthesiology Research Institute of Central South University, Changsha, Hunan, ChinaDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China; Anesthesiology Research Institute of Central South University, Changsha, Hunan, ChinaDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China; Anesthesiology Research Institute of Central South University, Changsha, Hunan, ChinaDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China; Anesthesiology Research Institute of Central South University, Changsha, Hunan, ChinaDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China; Anesthesiology Research Institute of Central South University, Changsha, Hunan, ChinaDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China; Anesthesiology Research Institute of Central South University, Changsha, Hunan, China; Corresponding authorDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China; Anesthesiology Research Institute of Central South University, Changsha, Hunan, China; Corresponding authorSummary: Platelets have a great ability to modulate immune responses. Monocyte-platelet aggregates (MPAs) are associated with the pathogenesis of cardiac disease. Notably, a low preoperative platelet count often indicates poor postoperative recovery following acute aortic dissection (AAD). The functions of platelets and MPAs in AAD, however, remain poorly understood. We found that, despite decreased platelet counts, platelets were also activated in AAD patients, with significant alterations in immune-modulating mediators. Of interest, monocytes in AAD patients had a suppressed immune status, which was correlated with poor outcomes following surgery. Interestingly, platelets preferentially aggregated with monocytes, and the levels of MPAs were related to recovery after surgical repair in AAD patients. Platelets restored suppressed monocyte functions in AAD patients by forming aggregates and partly by secreting matrix metalloproteinase-9 (MMP-9). Thus, the results point to a previously unknown mechanism for platelets involving monocyte reprogramming, which may improve postoperative outcomes following complex cardiovascular surgery.http://www.sciencedirect.com/science/article/pii/S2589004223008829Cardiovascular medicineImmunologySpecialized functions of cells |
| spellingShingle | Wei-Yun Shen Hui Li An-Hui Zha Ru-Yi Luo Yan-Ling Zhang Cong Luo Ru-Ping Dai Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection iScience Cardiovascular medicine Immunology Specialized functions of cells |
| title | Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection |
| title_full | Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection |
| title_fullStr | Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection |
| title_full_unstemmed | Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection |
| title_short | Platelets reprogram monocyte functions by secreting MMP-9 to benefit postoperative outcomes following acute aortic dissection |
| title_sort | platelets reprogram monocyte functions by secreting mmp 9 to benefit postoperative outcomes following acute aortic dissection |
| topic | Cardiovascular medicine Immunology Specialized functions of cells |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223008829 |
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