Successful debulking of plurihormonal pituitary macroadenoma with long‐acting pasireotide and dopamine agonist combination therapy
Key Clinical Message Long‐acting pasireotide and bromocriptine provided biochemical control of growth hormone and prolactin in a patient with plurihormonal pituitary macroadenoma, allowing near‐complete tumor excision while restoring pituitary function and avoiding adjunctive radiotherapy. Pasireoti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-03-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.1961 |
| _version_ | 1818265982892769280 |
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| author | Terri W. Jerkins Randy K. Jerkins Robbi Franklin |
| author_facet | Terri W. Jerkins Randy K. Jerkins Robbi Franklin |
| author_sort | Terri W. Jerkins |
| collection | DOAJ |
| description | Key Clinical Message Long‐acting pasireotide and bromocriptine provided biochemical control of growth hormone and prolactin in a patient with plurihormonal pituitary macroadenoma, allowing near‐complete tumor excision while restoring pituitary function and avoiding adjunctive radiotherapy. Pasireotide initiation resulted in hyperglycemia, which stabilized after a few months and resolved upon pasireotide discontinuation (ACCESS; NCT01995734). |
| first_indexed | 2024-12-12T19:59:28Z |
| format | Article |
| id | doaj.art-be137ffdadca4c1b9bb0a5938198c46d |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-12-12T19:59:28Z |
| publishDate | 2019-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-be137ffdadca4c1b9bb0a5938198c46d2022-12-22T00:13:48ZengWileyClinical Case Reports2050-09042019-03-017344545110.1002/ccr3.1961Successful debulking of plurihormonal pituitary macroadenoma with long‐acting pasireotide and dopamine agonist combination therapyTerri W. Jerkins0Randy K. Jerkins1Robbi Franklin2Midstate Endocrinology Associates Nashville TennesseeCollege of Pharmacy Lipscomb University Nashville TennesseeNashville Neurosurgery Group Nashville TennesseeKey Clinical Message Long‐acting pasireotide and bromocriptine provided biochemical control of growth hormone and prolactin in a patient with plurihormonal pituitary macroadenoma, allowing near‐complete tumor excision while restoring pituitary function and avoiding adjunctive radiotherapy. Pasireotide initiation resulted in hyperglycemia, which stabilized after a few months and resolved upon pasireotide discontinuation (ACCESS; NCT01995734).https://doi.org/10.1002/ccr3.1961endocrinologymetabolic disorderspasireotide and bromocriptine |
| spellingShingle | Terri W. Jerkins Randy K. Jerkins Robbi Franklin Successful debulking of plurihormonal pituitary macroadenoma with long‐acting pasireotide and dopamine agonist combination therapy Clinical Case Reports endocrinology metabolic disorders pasireotide and bromocriptine |
| title | Successful debulking of plurihormonal pituitary macroadenoma with long‐acting pasireotide and dopamine agonist combination therapy |
| title_full | Successful debulking of plurihormonal pituitary macroadenoma with long‐acting pasireotide and dopamine agonist combination therapy |
| title_fullStr | Successful debulking of plurihormonal pituitary macroadenoma with long‐acting pasireotide and dopamine agonist combination therapy |
| title_full_unstemmed | Successful debulking of plurihormonal pituitary macroadenoma with long‐acting pasireotide and dopamine agonist combination therapy |
| title_short | Successful debulking of plurihormonal pituitary macroadenoma with long‐acting pasireotide and dopamine agonist combination therapy |
| title_sort | successful debulking of plurihormonal pituitary macroadenoma with long acting pasireotide and dopamine agonist combination therapy |
| topic | endocrinology metabolic disorders pasireotide and bromocriptine |
| url | https://doi.org/10.1002/ccr3.1961 |
| work_keys_str_mv | AT terriwjerkins successfuldebulkingofplurihormonalpituitarymacroadenomawithlongactingpasireotideanddopamineagonistcombinationtherapy AT randykjerkins successfuldebulkingofplurihormonalpituitarymacroadenomawithlongactingpasireotideanddopamineagonistcombinationtherapy AT robbifranklin successfuldebulkingofplurihormonalpituitarymacroadenomawithlongactingpasireotideanddopamineagonistcombinationtherapy |