Association between visceral adiposity and generalized anxiety disorder (GAD)
Abstract Background and objectives Due to an increased rate of inflammation in generalized anxiety disorder (GAD), insight into the mediating factors in the onset and recurrence of the inflammatory response can help to achieve novel treatments for alleviating the risk of GAD. In the current study, w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Psychology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40359-024-01542-x |
| _version_ | 1797276213491793920 |
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| author | Ghazaleh Nameni Shima Jazayeri Masoud Salehi Ali Esrafili Ahmad Hajebi Seyed Abbas Motevalian |
| author_facet | Ghazaleh Nameni Shima Jazayeri Masoud Salehi Ali Esrafili Ahmad Hajebi Seyed Abbas Motevalian |
| author_sort | Ghazaleh Nameni |
| collection | DOAJ |
| description | Abstract Background and objectives Due to an increased rate of inflammation in generalized anxiety disorder (GAD), insight into the mediating factors in the onset and recurrence of the inflammatory response can help to achieve novel treatments for alleviating the risk of GAD. In the current study, we aimed to evaluate the possible relationship between visceral adipose tissue (VAT) as an important intermediary in inflammation pathways and GAD in participants of the Employees’ Health Cohort Study of Iran (EHCSIR). Method We analyzed the data from 3889 included participants aged > 18 years in the EHCSIR study, which were collected from 2017 to 2020. Lifetime and 12-month GAD were assessed using the Composite International Diagnostic Interview (CIDI-2.1) questionnaire. The adjusted prevalence ratio was computed to evaluate the association between GAD and visceral adiposity index (VAI), GAD and visceral fat area (VFA), GAD and body mass index (BMI) and ultimately GAD and waist circumference (WC) in males and females using STATA software. Results Log-binomial analysis showed a higher prevalence ratio of 12-month GAD associated with VFA in women [PR: 1.42, CI: 1.07–1.87, P: 0.015]. The prevalence of lifetime GAD was higher in obese women (BM1 > 30) [PR: 2.35, CI: 1.07–5.13, P:0.03] than in women with normal BMI. Women with higher VAI were also significantly more likely to suffer lifetime GAD [PR: 1.25, CI: 1.05]. 1.48, P:0.01]. In males, the prevalence of lifetime diagnosed GAD per 1 standard deviation increase in VFA was 0.65 [CI: 0.46–0.91, P: 0.01]. Conclusion Visceral adiposity as a positive agent was associated with GAD prevalence in women. The presence of GAD symptoms showed no relationship to VFA in men. |
| first_indexed | 2024-03-07T15:25:09Z |
| format | Article |
| id | doaj.art-be13b00496cb4102808265bf1c3dbda2 |
| institution | Directory Open Access Journal |
| issn | 2050-7283 |
| language | English |
| last_indexed | 2024-03-07T15:25:09Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychology |
| spelling | doaj.art-be13b00496cb4102808265bf1c3dbda22024-03-05T17:09:45ZengBMCBMC Psychology2050-72832024-01-011211810.1186/s40359-024-01542-xAssociation between visceral adiposity and generalized anxiety disorder (GAD)Ghazaleh Nameni0Shima Jazayeri1Masoud Salehi2Ali Esrafili3Ahmad Hajebi4Seyed Abbas Motevalian5Department of Nutrition, School of Public Health, Iran University of Medical Sciences Department of Nutrition, School of Public Health, Iran University of Medical Sciences Department of Biostatistics, School of Public Health, Iran University of Medical SciencesDepartment of Environmental Health Engineering, School of Public Health, Iran University of Medical SciencesResearch Center for Addiction & Risky Behaviors (ReCARB), Psychosocial Health Research Institute, Iran University of Medical SciencesDepartment of Epidemiology, School of Public Health, Iran University of Medical SciencesAbstract Background and objectives Due to an increased rate of inflammation in generalized anxiety disorder (GAD), insight into the mediating factors in the onset and recurrence of the inflammatory response can help to achieve novel treatments for alleviating the risk of GAD. In the current study, we aimed to evaluate the possible relationship between visceral adipose tissue (VAT) as an important intermediary in inflammation pathways and GAD in participants of the Employees’ Health Cohort Study of Iran (EHCSIR). Method We analyzed the data from 3889 included participants aged > 18 years in the EHCSIR study, which were collected from 2017 to 2020. Lifetime and 12-month GAD were assessed using the Composite International Diagnostic Interview (CIDI-2.1) questionnaire. The adjusted prevalence ratio was computed to evaluate the association between GAD and visceral adiposity index (VAI), GAD and visceral fat area (VFA), GAD and body mass index (BMI) and ultimately GAD and waist circumference (WC) in males and females using STATA software. Results Log-binomial analysis showed a higher prevalence ratio of 12-month GAD associated with VFA in women [PR: 1.42, CI: 1.07–1.87, P: 0.015]. The prevalence of lifetime GAD was higher in obese women (BM1 > 30) [PR: 2.35, CI: 1.07–5.13, P:0.03] than in women with normal BMI. Women with higher VAI were also significantly more likely to suffer lifetime GAD [PR: 1.25, CI: 1.05]. 1.48, P:0.01]. In males, the prevalence of lifetime diagnosed GAD per 1 standard deviation increase in VFA was 0.65 [CI: 0.46–0.91, P: 0.01]. Conclusion Visceral adiposity as a positive agent was associated with GAD prevalence in women. The presence of GAD symptoms showed no relationship to VFA in men.https://doi.org/10.1186/s40359-024-01542-xGeneralized anxiety disorderGADVisceral adiposityCross-sectional |
| spellingShingle | Ghazaleh Nameni Shima Jazayeri Masoud Salehi Ali Esrafili Ahmad Hajebi Seyed Abbas Motevalian Association between visceral adiposity and generalized anxiety disorder (GAD) BMC Psychology Generalized anxiety disorder GAD Visceral adiposity Cross-sectional |
| title | Association between visceral adiposity and generalized anxiety disorder (GAD) |
| title_full | Association between visceral adiposity and generalized anxiety disorder (GAD) |
| title_fullStr | Association between visceral adiposity and generalized anxiety disorder (GAD) |
| title_full_unstemmed | Association between visceral adiposity and generalized anxiety disorder (GAD) |
| title_short | Association between visceral adiposity and generalized anxiety disorder (GAD) |
| title_sort | association between visceral adiposity and generalized anxiety disorder gad |
| topic | Generalized anxiety disorder GAD Visceral adiposity Cross-sectional |
| url | https://doi.org/10.1186/s40359-024-01542-x |
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